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Michael > PK/PD > Flashcards

PK/PD Flashcards

0
Q

Clearance determines..

A

The maintenance dose

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1
Q

Four primary first pass metabolism systems

A

Gut lumen enzymes
Gut wall enzymes
Bacterial enzymes
Hepatic enzymes

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2
Q

Volume of distribution determines the…

A

Loading dose

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3
Q

Egs of drugs that utilize enterohepatic circulation

A

Oral contraceptives

TCAs

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4
Q

Inducers include

A 
Phenytoin
Efavirenz
Nevirapine
Rifampicin
Carbamazepine
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5
Q

Inhibitors include

A 
Macrolides
Azoles
Protease inhibitors
Efavirenz
Cimetidine
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6
Q

Inhibition occurs… But induction occurs…

A

Rapidly

More slowly

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7
Q

Egs of drugs that exhibit tolerance

A

Nitrates
Opiates
Beta-agonists

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8
Q

Drugs that have withdrawal symptoms

A 
Opiates
Alcohol
Benzodiazepines 
Beta-blockers
Corticosteroids
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Michael (7 decks)

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