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Michael > Mood Disorders > Flashcards

Mood Disorders Flashcards

0
Q

What drugs can induce depression

A 
B-blockers, CCB
Benzodiazepines 
Methyldopa 
Corticosteroids 
Anabolic steroids
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1
Q

Egs of mood disorders

A 
Major depressive disorder
Bipolar mood disorder
Dysthymia (over to years) in adult 1 in kids)
2ndry to medical conditions
Substance induced
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2
Q

What amino acid is needed to make serotonin

A

Tryptophan

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3
Q

Eg of an SSRI

A

Fluoxetine

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4
Q

MOA of SSRI

A

Selective and potent inhibition of serotonin re uptake via inhibition of the serotonin transporter.

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5
Q

A/E for SSRIs

A

GIT - nausea, vomiting
Sexual - anorgasmia, delayed ejaculation, impotence
CNS - akathisia, psychomotor retardation, Parkinsonism, dystonic reactions. Agitation, anxiety, panic attacks.

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6
Q

Signs of serotonin syndrome

A

Neuromuscular hyperactivity- tremor, clonus, hyperreflexia

Altered mental state - agitation, excitement

Autonomic hyperactivity - fever, sweating, tachycardia, tachypnoea, diarrhoea

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7
Q

Two examples of TCAs

A

Amitriptyline

Imipramine

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8
Q

Contraindications for SSRI

A

Renal failure
MAOI therapy (5 week gap needed)
Pregnancy
Lactation

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9
Q

Indications for TCA use

A

Depression
Anxiety
Nocturnal enuresis

Analgesic (adjunctive) in chronic pain syndromes

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10
Q

MOA of TCAs

A

Inhibit the reuptake of noradrenaline and 5HT in central monoamine synapses.

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11
Q

Side effects of TCAs

A

M1 - constipation, dry mouth, blurred vision

H1 - weight gain, drowsiness

A1 - dizziness, hypotension

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12
Q

Result of TCA overdose

A

Coma
Seizure
Arrhythmias
Cardiac arrest

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13
Q

Indications for lithium

A

Prophylaxis of manic and hypomanic episodes

Augmentation of antidepressant therapy

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14
Q

Two egs of anticonvulsants used in management of mania

A

Sodium valproate

Carbamazepine

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15
Q

MOA of benzodiazepines

A

Enhance GABA transmission by:

  • Allosteric enhancement of Cl conduction
  • Increasing frequency of channel opening
  • Therefore hyperpolarisation
16
Q

Indications for benzodiazepines

A 
Anxiety disorder 
Management of alcohol withdrawal
Seizure disorders
Muscle relaxant
Acute sedation
17
Q

ADRs to benzodiazepines

A

Common - drowsiness, over sedation, amnesia

Uncommon - depression, disorientation, confusion, slurred speech, lethargy, ataxia

Paradoxical (children) - hyperexcitability, agitation

Dependence [more common in short acting]

18
Q

How to wean off benzodiazepines

A

Slow step wise reduction of dose by 10% every 2-4 weeks

19
Q

What is used in benzodiazepine overdose and how does it work

A

Flumazenil. Binds competitively to the benzodiazepine receptor. Can cause benzodiazepine withdrawal leading to seizures.

Michael (7 decks)

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