PK As Illustrated By Insulin

Question 1

Pk studies?

Answer 1

Effect of body on the drug

Question 2

Some PD effects of insulin:

Answer 2

Glucose uptake by fat and muscle
Increased fat and glycogen synthesis
Reduction of catabolic processes like proteolysis and lipolysis

Question 3

Human insulin clearance

Answer 3

Rapid, approximately 40 l/hour
1st order kinetics

Question 4

Assumptions of one compartment model

Answer 4

Any drug within compartment is distributed evenly and instantaneously
Volume remains constant during the period under study
Rate of drug removal is proportional to the amount present

Question 5

Half life-equation=

Answer 5

Ln(2) V / Cl