concentration effect curve Flashcards
Generally when conducting an experiment we see that effect increases towards some sort of maximum, with a diminishing return at increasing doses . The relationship is non-linear, sometimes described as a?
hyperbolic line
the law of mass action proposes that?
the rate of a chemical reaction is proportional to the product of the concentration of the reactants
When [D]=Kd, the concentration of drug [D] is enough to?
50% of the total receptors
why is a sigmoid curve more useful to describe the link between conc. and effect?
more useful info about changes in concentration & response.
more info. about conc at lower doses
EC 20 is
1/4 of EC50
EC 80 is
4 times EC 50
to represent multiple binding sites e.g. O2(binding sites for Hb) what do we use? as changes arent met by the standard Emax model?
hill coeeficient
inflection model
the point at which the steepness increases & then decreases again
where is inflection normally found?
found at EC50 for the Emax model
where is inflection normally found?
found at EC50 for the Emax model
