PK

Question 1

Name HLA-B associated drugs

Answer 1

Abacavir, allopurinol, CBZ and phenytoin

Question 2

Equation for bioavailability

Answer 2

F = Div X AUCev/(Dev X AUCiv)

Question 3

What is the PHY correction equation?

Answer 3

PHY/(0.1 X Alb + 0.1)

Question 4

What drug needs to dose reduced for both loading dose and maintenance dose in renal function?

Answer 4

Digoxin

*normally loading dose is not altered unless Vd is altered secondary to renal dysfunction (digoxin Vd is reduced)

Question 5

What drugs are low-hepatic extraction ratio drugs that may require dose reduction of loading dose?

Answer 5

CBZ, diazepam, PHY and warfarin

Question 6

How are high-hepatic extraction ratio drugs impacted in hepatic dysfunction? With IV and PO drugs?

Answer 6

IV: necessary to decrease maintenance dose as hepatic blood flow changes
PO: Decrease maintenance dose since it alters clearance (ex: haloperidol, morphine, metoprolol, propranolol, verapamil)