Endocrine Metabolic disorders

Question 1

What are symptoms of hyperthyroidism?

Answer 1

Weight loss, increased appetite, heat intolerance, heart palpitations, tachycardia, sweating

Question 2

What agent should be used during the first trimester of pregnancy for hyperthyroidism?

Answer 2

Propylthiouracil

Question 3

What is first line for hyperthyroidism?

Answer 3

Methimazole due to lower hepatotoxicity compared to PTU though not necessarily more efficacious

Question 4

When are iodine based therapies indicated for hyperthyroidism?

Answer 4

Before surgery during resection or during thyroid storm

Question 5

What is the clinical presentation of hypothyroidism?

Answer 5

Cold intolerance, dry skin, fatigue, weight gain, bradycardia, slow reflexes

Question 6

What special populations would you want to lower the dose of levothyroxine therapy?

Answer 6

50-60 years of age, consider 50 mcg/day

Existing cardio disease consider 12.5-25 mcg/day

Question 7

What therapeutic agents are used for acromegaly?

Answer 7

Dopamine agonists (bromocriptine, cabergoline) and somatostatin analog (octreotide) which decreases GH production

Question 8

What therapeutics are used refractory to surgical resection of tumor for hyperprolactinemia?

Answer 8

Dopamine agonists (Cabergoline, bromocriptine)