Gen Psych Flashcards

1
Q

What black box warning is there for use of antipsychotics?

A

Dementia

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2
Q

What black box warning indicates REMS for clozapine?

A

Severe neutropenia (agranulocytosis)

Discontinue at ANC < 1000

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3
Q

What second gen antipsychotic carries a warning for eosinophila and systemic symptoms (DRESS)?

A

Ziprasidone

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4
Q

Which second gen antipsychotic is preferred in parkinson patients?

A

Quetiapine

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5
Q

Which 2nd gen antipsychotics have long-acting depot injectables?

A

Aripiprazole, olanzapine, paliperidone, risperidone

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6
Q

Which 2nd gen antipsychotic agents have higher EPS risk?

A

Lurasidone, risperidone

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7
Q

Which first generation antipsychotics have the highest EPS risk?

A

Fluphenazine, haloperidol, thiothixene

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8
Q

Describe lithium toxicity

A

Rash, tremor, CNS toxicity, GI, hypothyroidism, polydipsia/polyuria, teratogenecity

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9
Q

What agents increase lithium concentrations?

A

Thiazides, NSAIDs, ACEIs, decreased renal function, dehydration

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10
Q

What agents can be used as adjunctive acute mania agents?

A

Divalproex, carbamazepine

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11
Q

What agents can be used for maintenance therapy?

A

Lamotrigine

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12
Q

What agents can be used for bipolar depression?

A

Quetiapine and lurasidone

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13
Q

What SGAs can be used for maintenance therapy for bipolar disorder?

A

Risperidone, apriprazole

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14
Q

What is first line with generalized anxiety disorder?

A

First line: SSRIs and SNRIs

2nd line: BZDs, buspirone

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15
Q

What is first line with panic disorders?

A

First line: SSRIs

2nd line: BZDs

Buspirone, antipsychotics, buprioron not effective

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16
Q

What is first line for OCD?

A

SSRIs, clomipramine

Augmentation with haloperidol or SGA may help

17
Q

What is first line for PTSD?

A

First line: SSRIs

Can use augmentation with other agents to treat specific symptoms

Nightmares: prazosin
Aggression, anger, depression: anticonvulsants
Psychotic symptoms: atypical antipsychotics

18
Q

Which non-BZD agents are indicated for sleep maintenance?

A

Doxepin, eszopiclone, suvorexant, zolipdem (CR only)