Gen Psych Flashcards
What black box warning is there for use of antipsychotics?
Dementia
What black box warning indicates REMS for clozapine?
Severe neutropenia (agranulocytosis)
Discontinue at ANC < 1000
What second gen antipsychotic carries a warning for eosinophila and systemic symptoms (DRESS)?
Ziprasidone
Which second gen antipsychotic is preferred in parkinson patients?
Quetiapine
Which 2nd gen antipsychotics have long-acting depot injectables?
Aripiprazole, olanzapine, paliperidone, risperidone
Which 2nd gen antipsychotic agents have higher EPS risk?
Lurasidone, risperidone
Which first generation antipsychotics have the highest EPS risk?
Fluphenazine, haloperidol, thiothixene
Describe lithium toxicity
Rash, tremor, CNS toxicity, GI, hypothyroidism, polydipsia/polyuria, teratogenecity
What agents increase lithium concentrations?
Thiazides, NSAIDs, ACEIs, decreased renal function, dehydration
What agents can be used as adjunctive acute mania agents?
Divalproex, carbamazepine
What agents can be used for maintenance therapy?
Lamotrigine
What agents can be used for bipolar depression?
Quetiapine and lurasidone
What SGAs can be used for maintenance therapy for bipolar disorder?
Risperidone, apriprazole
What is first line with generalized anxiety disorder?
First line: SSRIs and SNRIs
2nd line: BZDs, buspirone
What is first line with panic disorders?
First line: SSRIs
2nd line: BZDs
Buspirone, antipsychotics, buprioron not effective