PK

Question 1

What is bioavailability ?

Answer 1

Fraction of unchanged drug that reaches systemic circulation following administration (by any Route of Administration)
IV administration: bioavailability = 1 (100 %)
Other routes of administration = < 1 (=<100 %)

Question 2

What’s the important of Pk ?

Answer 2

1- Define the factors that influence the levels and persistence of a drug dose in the body.
2- Determine the therapeutic use of drugs.

Question 3

What’s the factors that affect Bioavilability ?

Answer 3

First pass
In complete absorption

Question 4

What’s the relation btw VD and EVC ?

Answer 4

Directly proportional

Question 5

What is VD ?

Answer 5

volume that required by the drug to be uniformly distributed in to produce a specific drug concentration in the plasma.

Question 6

When is VD increases ?

Answer 6

Renal failure
Liver failure ( reduce plasma protein )

Question 7

When is VD decrease ?

Answer 7

Dehydration

Question 8

What is the clinical applications of VD ?

Answer 8

Calculate : drug conc in blood
H life - loading dose - drug clearance - steady state

Question 9

What is EVC ?

Answer 9

It is intracellular + interstitial volume
28+10=38

Question 10

What is IVC ?

Answer 10

Plasma volume =4

Question 11

Calculate VD

Answer 11

VD = dose / con