Excretion

Question 1

What is execrations and where it occur ?

Answer 1

Removal of drugs from the body

kidney in the urine.( most important )
bile, intestine, lungs, or milk in nursing mothers.

Question 2

What is the mechanisms of execration ?

Answer 2

Glomerular filtration Station.
Tubular secretion Station.
Tubular reabsorption Station.

Question 3

Glomerular filtration:

Answer 3

Drugs enter the kidney through renal arteries which divide to form a glomerular capillary plexus.

Free drugs with low molecular weight flow through the capillary slits into Bowman’s space

Question 4

Drug flow through the capillary slits into Bowman’s space by ?

Answer 4

the force of the blood hydrostatic pressure

Question 5

GFR ?
RPF?

Answer 5

GFR = 125 ml/min
RPF = 600 ml /min

Question 6

Proximal tubular secretion:

Answer 6

Drugs that were not transferred into glomerular filtrate will leave the glomeruli through efferent arterioles: which divide to form a capillary plexus surrounding the nephric lumen in the proximal tubules

Question 7

What’s the aim of Manipulating the pH of the urine

Answer 7

Minimize the amount of the back diffusion (reabsorption).
Increase the clearance of the undesirable drug