Gentic

Question 1

CYP2D6

Answer 1

70 SNP
4 phenotypic subpopulation of mrtabolizer
PM - IM - EM - UM

Greater likelihood of adverse ration in PM
In UM dose not enough

Metabolize 65% of commmon drug
Tricycilc antidepressant
Antirrhythic agents
B-andrenegic antagonists

Question 2

CYP2C19

Answer 2

Aromatic hydroxilation of anticonvulsant drug mephenytion
Cussain and Japanese Asian poor motabolzer

Question 3

CYP2C9

Answer 3

Variation among Caucasian
CYP2C92 impaired interaction with CYP reductase
CYP2C93 reduce tolerance of anticoagulant warfarin : 10% clearance - less tolerance - bleeding

Phenytoin
Tolbutamid - cardiotoxictiy -
NSAIDs