Pituitary Drugs

Question 0

Pegvisomant

Answer 0

GH antagonist
Uses: acromegaly
SE: HTN, periph. edema, enlarge pituitary adenoma(s), elevated liver f(x) tests

Question 1

Octreotide

also: Sandostatin, Lanreotide

Answer 1

Somatostatin analog
–l GH secretion
Uses: acromegaly, functional pancreatic/carcinoid tumors
SE: nausea, diarrhea, abdominal pain

Question 2

Bromocryptine mesylate

Answer 2

DA agonist,
=> suppress prolactin, & GH (paradoxically); lowers glucose.
Uses: hyperprolactinemic disorders, acromegaly, DM2
SE: orthostatic hypotension/dizziness, headache, fatigue, digital vasospasm

Question 3

Cabergoline

Answer 3

ergot deriv => suppresses prolactin
Uses: hyperprolactinemic disorders
SE: orthostatic hypotension/dizziness, headache, cardiac valve disease if prolonged use.

Question 4

Somatropin, Somatrem

Answer 4

Recombinant human GH
Uses: failed growth (GH def, Turner’s, Prader-Willi, cachexia, chronic kidney disease)
SE: transient flushing, Ab development, injection site rxn

Question 5

Sermorelin

Answer 5

GH Releasing Hormone Analog
Use: to Dx low plasma GH, to Tx GH def. in kids
SE: transient flushing, Ab development, injection site rxn

Question 6

Mecasermin

Answer 6

recombinant human IGF-1
Uses: Laron dwarfism, GH def. bc neutralizing GH Abs
SE: hypoglycemia, seizure/increased ICP, slipped femoral epiphysis