Growth Drugs

Question 1

Somatropin

Answer 1

recombinant Human Growth Hormone;
Use: GH deficiency in kids or adults, Turner’s syndrome, Prader-Willi syndrome, CKD, cachexia
SE: transient flushing, injection site rxns, Ab dvpt

Question 2

Somatrem

Answer 2

methionated human Growth Hormone;
Use & SE: same as somatropin
(GH def, Turner’s, prader-willi.; SE flushing, site rxn, etc)

Question 3

Sermorelin acetate

Answer 3

GHRH R analog
Use: to Dx low plasma GH, & Tx for GH def. in kids
SE: flushing, Ab dvpt

Question 4

mecasermin

Answer 4

recombinant IGF-1,
Use: Laron dwarfism, GH def. bc neutralizing GH Abs
SE: hypoglycemia, seizure, increased ICP, slipped upper femoral epiphysis

Question 5

octreotide

Answer 5

somatostatin analog => inhibits GH secretion
Use: Acromegaly, functional pancreatic or carcinoid tumors, esophageal variceal bleeds
SE: nausea, diarrhea, abdominal pain
*decreases portal P!

Question 6

Pegvisomant

Answer 6

PEGylated GH,
Use: acromegaly, functional pancreatic or carcinoid tumors
SE; increase size of pit. adenomas, elevated LFTs, HTN, peripheral edema

Question 7

Bromocriptine mesylate

Answer 7

ergot deriv, suppresses prolactin & GH (paradoxiacally); *also lowers glucose!
Use: hyperprolactin disorders, acromegaly, DM2
SE: dizzy, orthostatic hypOtension, headache, GI, fatigue, digital spasm