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Human development > Pituatry clinical > Flashcards

Pituatry clinical Flashcards

1
Q

A hormone is?

A

secreted

bioactive messenger

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2
Q

A hormone can

A

travel in blood
effect target cell
stimulate/inhibit
maintain physiological state

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3
Q

how big is the thyroid gland

A

10-15g

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4
Q

thyroxine is?

A

iodide + tyrosine

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5
Q

thyroxine stored where

A

gland

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6
Q

thyroxine secreted to

A

blood

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7
Q

order, releasing factor…

A

Releasing factor
tropic hormone
target hormone
response

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8
Q

name releasing factor.. Thyroid axis

A

Hypothalamus:
Thyrotropin releasing hormone
(TRH)

Pituitary:
Thyroid stimulating hormone
(TSH)

Thyroid:
Thyroxine and triiodothyronine
(T4 and T3)

End Organ(s):
Basal metabolic rate, pulse
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9
Q

Hypothyroidism deficiency 1st

A

Thyroid (T3/T4)

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10
Q

Hypothyroidism deficiency 2nd

A

pituitary (TSH)

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11
Q

Hypothyroidism deficiency 3rd

A

Hypothalamus (TRH)

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12
Q

Hypothyroidism Resistance

A

Periphery (P, BMR)

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13
Q

Pituitary sits in

A

pituitary fossa

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14
Q

pituitary fossa is in

A

in sphenoid bone

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15
Q

Cavernous sinus contains

A

Internal carotid Artery

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16
Q

Posterior Pituitary makes

A

ADH + Oxytocin

17
Q

Anterior pituitary makes

A

6 tropic hormones

18
Q

Lesion of the optic chiasm causes

A

Bitemporal hemianopia (visual field )

19
Q

bitemporal hemianopia caused by

A

optic chiasm is compressed

20
Q

Symptoms of endocrine diseases

A

Shave less freq
Libido decrease
Reduce energy
Gained weight

21
Q

Anterior pituitary is

A

Vascular network connected to hypothalamus

22
Q

Anterior pituitary hormones

A 
TSH
ACTH
FSH+LH
GH
PROLACTIN
23
Q

TSH—>

A

thyroid—> thyroxine

influnces metabolic rate

24
Q

ACTH—->

A

adrenals–> cortisol

influences stress response

25
Q

FSH + LH—>

A

gonads—> testo/estadriol

sperm, ova

26
Q

GH—>

A

liver—> IGF-1

vertical growth, bonemass, metabolism

27
Q

PRL —>

A

Breast –> lactation

28
Q

The bigger the tumour the more it..

A

compresses the stalk

29
Q

Test of hypofunction

A

Measure the pituitary and target hormone

30
Q

Endocrine evaluation

A 
Clinical symptoms
confirm abnormality of target hormone
determine part of axis that's abnormal by measuring each level
localise site of abnormality 
identify pathology
31
Q

What % of macro Adenomas are non secreting

A

50

32
Q

Ways in which pituitary tumours present

A 
Mass effect 
Hypoventilation 
Incidental
Hyper function
Apoplexy/ haemorrhage
33
Q

Treatment-

A

Surveillance
Surgery
Medical
Radiotherapy

34
Q

Principles of hormone replacement :

Goal of treating hypopituitarism is to

A

Replace hormones

35
Q

Replacement needs to

A

Recognise digital variations and natural evolution of hormones over time

Human development (9 decks)

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