Pictures Flashcards
1
Q
identify
A
ulcer on neonate d/t HSV-1
2
Q
identify
A
neonated with disseminated HSV infection
3
Q
identify
A
erosions from ruptured vesicles
primary HSV infection
4
Q
label
A
Cowdry Type A bodies: esionophillic cytoplasmic inclusions
seen in HSV infection
5
Q
identify and label
A
6
Q
identify
A
molluscum contagiosum, gross
7
Q
identify
A
molluscum contagiosum miscroscopic
dome-shaped papule with dimpled center
8
Q
identify
A
molluscum contagiosum miscroscopic
dome-shaped papule with dimpled center
9
Q
identify
A
molluscum body - esiononophillic nuclear viral (pox virus) inclusion
mollscum contagiosum
10
Q
identify
A
molluscum body - esiononophillic nuclear viral (pox virus) inclusion
mollscum contagiosum
11
Q
identify
A
papillary, exophytic growth
condyloma acuminatum
12
Q
identify
A
exophytic papillomas with broad base and fibrovascular cores
condyloma acuminatum
13
Q
identify
A
koilocytes (clear perinuclear halos w/ wrinkled, hyperchromatic nuclei)
condyloma acuminatum
14
Q
identify
A
bartholin duct cyst
15
Q
identify
A
epithelium surrounding residual mucinous glands
bartholin duct cyst
16
Q
identify
A
lymphocytic band (lichenoid) beneath atrophic epidermis
lichen sclerosis
17
Q
identify
A
pale pink to white dry, scaly plaques - “parchment paper” skin
lichen sclerosis
18
Q
identify
A
full thickness atypia with minimal maturation
U-VIN
19
Q
identify
A
atypia in basal layers, superficial maturation
D-VIN
20
Q
identify
A
white, firm mass, with raised borders +/- central ulceration
vulvar squamous cell carcinoma
21
Q
invasive squamous cell carcinoma
A
keratin pearls, stroma is desmoplastic
invasive squamous cell carcinoma
22
Q
identify
A
well circumscribed skin colored nodules
papillary hidrademoma
23
Q
identify
A
anastomosing, branching papillae lined with two layers: outer myoepithelium and inner cuboidal-columnar
papillary hidradenoma
24
Q
identify
A
red, moist pruritic lesions that appears likely inflammation
extramammary paget disease
25
identify
atypical cells with **abundant pale cytoplasm** (mucous filled cytoplasm)
extramammary paget disease
26
identify
atypical cells with **abundant pale cytoplasm**
_+ mucarmine stain:_ stains pink d/t intra-cytoplasmic mucin
extrammmary paget disease
27
identify
* atypical melanocytes
* resembles extrammary pagets disease
* **mucicarmine stain -**
vulvular melanoma
28
identify
**white curd-like deposits** on vaginal wall
vulvovaginal candidiasis
29
identify
**psuedohyphae** and _rare budding yeast_ (curved arrow)
vulvovaginal candidiasis
30
identify
psuedohyphae piercing epithelial cells
vulvovaginal candidiasis
31
identify
label
black arrow: hyphae and pseudohyphae (GMS stain) oriented vertically
vulvovaginal candidia
32
identify
**trophozoites:** unicellular, flagellated, protazoan parasite
trichomoniasis vaginalis
33
identify
trophozoites + neutrophils
trichomoniasis vaginalis
34
identify
**clue cells:** coccobacilli covering squamous cells
garderella vaginalis
35
label
identify
1. **actetowhite lesion with sharp borders**
2. normal squamous vaginal epithelium
3. region of HPV infection
36
identify
koilocytic changes
VaIN
37
identify
**polypoid mass**
embryoyal rhabdoomyosarcoma
38
identify
**botryoides ("grape-like")** polyploid, rounded bulky masses
embryonal rhabdomyosarcoma
39
identify
**“tennis raquet” tumor cells -** _oval nuclei_ with ill defined cytoplasm that sometimes extends in a “whisp”
embryonal rhabdomyosarcoma - microscopic
40
what clinical features are _shared_ vs _not shared_ by complete and partial hydratiform moles?
* both:
* increase risk of persistent hydratiform mole
* are successully removed by curretage
* complete hydratiform role:
* **embryo dies early and is usually not identified**
* **hGC levels greatly exceed** those of a normal pregnancy of similar gestational age
* risk of **invasive mole** is increased
* risk of **choriocarcinoma** is increased
* incomplete hydratiform mole
* **fetal remnants present**
* NO risk of invasive mole/ choriocarcinoma
41
invasive mole
* definition
* clinical characteristics
* a complete hydratiform mole **that penetrates/perforates the myometrium**
* comes from a complete hydratiform role
* clinical characteristics
* associated with major increased in HcG
* presents with vaginal bleeding and irregular uterine enlargement
42
partial hydratiform mole
43
identify picture, note important features
partial hydratiform mole
_mixture_ of small villi and enlarged, proliferating villi (not all villi affected)
central cistern seen
44
complete hydratiform mole
45
complete hydratiform mole
**scalloped, enlarged** villi (all villi affected)
46
tumors, characteristics
benign serous tumor
* **typically unilateral**
* morphology:
* gross
* **smooth external/internal surfaces**
* straw color fluid
* no stroma
47
tumor, characteristics
benign serous tumor
* **typically unilateral**
* morphology:
* microscopic:
* _single layer_ of _bland looking_ (usually ciliated columnar) epithelial cells
48
tumor, characteristics
borderline serous tumor
* microscopic- **stratification** of epithelium (multiple layers)
49
tumor, characteristics
borderline serous tumor - gross
* microscopic- **stratification** of epithelium (multiple layers)
* gross
* **inc # of papillary projections**
* still no stroma
50
serous tumor (adenocarcinoma)
51
tumor, characteristics
low grade serous tumor (adenocarcinoma)
* type I carcinomas
* genetics
* wild type p53
* morphology
* extensively papillary
* **with MANY psammoma bodies**
* **some fibrous stroma**
52
tumor, characteristics
high grade serous tumor (adenocarcinoma)
* high grade → type II carcinomas
* genetics
* high frequency of p53 mutations
* BRCA-1 & 2 tends to cause these
* morphology
* papillary, inc arcitechtural complexity
* **+/- psammoma bodies**
* **stromal invasion**
53
BRCA-1 and BRCA-2 patients mostly have what type of ovarian cancer?
high grade serous carcinomas with TP-53 mutations
54
mucinous tumor
* general characteristics
* benign, borderline and malignant morphologies, genetics
* general characteristics
* **almost entirely unilateral**
* **KRAS mutations are common**
* **two types: intestinal \> endocervical**
* **metastasis uncommon**
* types
* benign
* gross: **multi-cystic mass with delicate septa**
* micro: **tall, columnar epithelium without cilia**
* borderline
* intestinal type
* gross: **multilocular cysts filled with gelatinous contents**
* microscopic
* **epithelial stratification** (multiple layers)
* **tufting, budding**
* **endo-cervical type**
* gross - **unilocular cysts**
* microscopic **- heirarchal branching of papillae**
* **malignant**
* **confluent glandular growth of very closely packed glands**
55
tumor, characteristics
benign mucinous tumor (cystadenoma) - gross
* general characteristics
* **almost entirely unilateral**
* **KRAS mutations are common**
* **two types: intestinal \> endocervical**
* **metastasis uncommon**
* gross: **multi-cystic mass with delicate septa**
* micro: **tall, columnar epithelium without cilia**
56
benign mucous tumor (cystadenoma) - micro
* general characteristics
* **almost entirely unilateral**
* **KRAS mutations are common**
* **two types: intestinal \> endocervical**
* **metastasis uncommon**
* gross: **multi-cystic mass with delicate septa**
* micro: **tall, columnar epithelium without cilia**
57
tumor, characteristics
mucinous borderline tumor - intestinal type (gross)
* gross: **multilocular cysts filled with gelatinous contents**
* microscopic
* **epithelial stratification** (multiple layers)
* **tufting, budding**
general characteristics
* **almost entirely unilateral**
* **KRAS mutations are common**
* **two types: intestinal \> endocervical**
* **metastasis uncommon**
58
tumor, characteristics
mucinous borderline tumor - intestinal type (gross)
* gross: **multilocular cysts filled with gelatinous contents**
* microscopic
* **epithelial stratification** (multiple layers)
* **tufting, budding**
general characteristics
* **almost entirely unilateral**
* **KRAS mutations are common**
* **two types: intestinal \> endocervical**
* **metastasis uncommon**
59
endocervical borderline mucinous carcinoma
more rare presentation (intestinal type m/c)
* “papillary heirarchy”
* different than benign tumors d/t inc stratification
60
krukenberg tumor
* a metastatic tumor
* type of **non-mullerian tumor, derived from the GI tract**
* m/c non-mullerian tumors are from the **GI tract** or **breast**
* (note that metastatic tumors to the ovary - tho - are usually of _mullerian origin_: uterus, fallopian tube, perionteum, contralateral ovary)
* presentation:
* gross - **bilateral ovary involvement**
* microscopic - **singlet ring cell**
61
krukenberg tumor
* a metastatic tumor
* type of **non-mullerian tumor, derived from the GI tract**
* m/c non-mullerian tumors are from the **GI tract** or **breast**
* (note that metastatic tumors to the ovary - tho - are usually of _mullerian origin_: uterus, fallopian tube, perionteum, contralateral ovary)
* presentation:
* gross - **bilateral ovary involvement**
* microscopic - **singlet ring cell**
62
yolk sac tumor (type of germ cell tumor)- presence of schiller duvall bodies
* seen in children or young women
* + for alpha-feto protein
63
stroma ovarii (type of monodermal or highly specialized teratoma)
* monodermal/highly teratomas
* a type of **germ cell tumor**
* always **unilateral**
* most common types are
* **stroma ovariii** and **carinoid ovarri. both**
* can cause hyperthyroidism
* stroma ovarii is made entirely of thyroid tissue (shown in this pic)
64
dysgerminoma
* most common ovarian malignant germ cell tumor
* is the ovarian counterpart of a testicular seminoma
* bulky, tan lobulated tumors
65
immature (malignant) cystic teratoma
* type of germ cell tumor
* unlike the mature (benign) cystic teratoma - which is seen in women in **reproductive age**- this tumor is seen in
* **pre-pubertal adolescents** and young women (**avg age 18**)
66
acute salpingitis: many **neutrophils** in the MUCOSA
67
pyosalpinx: dilated fallopian tube FILLED with pus - i.e., **lumen** filled with neutrophils
68
chronic salpingitis: neutrophillic infiltate + **blunting of villi**
69
chronic salpingitis: neutrophillic infiltate + **blunting of villi**
70
hydrosalpinx
* progression from chronic salingitis
* neutrophilic infiltrate has been replaced with **CLEAR FLUID**
* tube walls - _d/t loss of villi_ - **are very smooth** instead of folded
71
hydrosalpinx
* progression from chronic salingitis
* neutrophilic infiltrate has been replaced with **CLEAR FLUID**
* tube walls - _d/t loss of villi_ - **are very smooth** instead of folded
72
tubal (ectopic pregnancy)
* risk factors
* etiology
* morphology
* gross
* microscopic
* sequelae
* biggest risk factor: **chronic salpingitis** (recall - appearance = neutrophilic lumen + _villous blunting_)
* etiology: ovum implants into tubal epithelium, then
* chorionic villi, extra-villous trophoblast grow within lumen or into tubal wall, while,
* maternal vessels grow into gestational sac
* morphology:
* gross: **hematosalpinx** (blood in fallopian tube) d/t maternal vessels → gestational sac
* microscopic: **intraluminal chorionic villi & extravillous trophpoblast** +/- embryonic parts
* sequelae: **tubal rupture → intra-abdominal hemorrhage** (life threatening)
73
ruptured tubal pregnancy
(complication of tubal ectopic pregnancy)
**white center:** tiny embryo remnant
74
outer surface of ovary - dusky red & enlarged
tubo-ovarian torsion
75
cut surface of ovary - **hemorrhagic & cystic**
tubo-ovarian torsion
