Pictures Flashcards
identify
ulcer on neonate d/t HSV-1
identify
neonated with disseminated HSV infection
identify
erosions from ruptured vesicles
primary HSV infection
label
Cowdry Type A bodies: esionophillic cytoplasmic inclusions
seen in HSV infection
identify and label
identify
molluscum contagiosum, gross
identify
molluscum contagiosum miscroscopic
dome-shaped papule with dimpled center
identify
molluscum contagiosum miscroscopic
dome-shaped papule with dimpled center
identify
molluscum body - esiononophillic nuclear viral (pox virus) inclusion
mollscum contagiosum
identify
molluscum body - esiononophillic nuclear viral (pox virus) inclusion
mollscum contagiosum
identify
papillary, exophytic growth
condyloma acuminatum
identify
exophytic papillomas with broad base and fibrovascular cores
condyloma acuminatum
identify
koilocytes (clear perinuclear halos w/ wrinkled, hyperchromatic nuclei)
condyloma acuminatum
identify
bartholin duct cyst
identify
epithelium surrounding residual mucinous glands
bartholin duct cyst
identify
lymphocytic band (lichenoid) beneath atrophic epidermis
lichen sclerosis
identify
pale pink to white dry, scaly plaques - “parchment paper” skin
lichen sclerosis
identify
full thickness atypia with minimal maturation
U-VIN
identify
atypia in basal layers, superficial maturation
D-VIN
identify
white, firm mass, with raised borders +/- central ulceration
vulvar squamous cell carcinoma
invasive squamous cell carcinoma
keratin pearls, stroma is desmoplastic
invasive squamous cell carcinoma
identify
well circumscribed skin colored nodules
papillary hidrademoma
identify
anastomosing, branching papillae lined with two layers: outer myoepithelium and inner cuboidal-columnar
papillary hidradenoma
identify
red, moist pruritic lesions that appears likely inflammation
extramammary paget disease
identify
atypical cells with abundant pale cytoplasm (mucous filled cytoplasm)
extramammary paget disease
identify
atypical cells with abundant pale cytoplasm
+ mucarmine stain: stains pink d/t intra-cytoplasmic mucin
extrammmary paget disease
identify
- atypical melanocytes
- resembles extrammary pagets disease
- mucicarmine stain -
vulvular melanoma
identify
white curd-like deposits on vaginal wall
vulvovaginal candidiasis
identify
psuedohyphae and rare budding yeast (curved arrow)
vulvovaginal candidiasis
identify
psuedohyphae piercing epithelial cells
vulvovaginal candidiasis
identify
label
black arrow: hyphae and pseudohyphae (GMS stain) oriented vertically
vulvovaginal candidia
identify
trophozoites: unicellular, flagellated, protazoan parasite
trichomoniasis vaginalis
identify
trophozoites + neutrophils
trichomoniasis vaginalis
label
identify
- actetowhite lesion with sharp borders
- normal squamous vaginal epithelium
- region of HPV infection
identify
koilocytic changes
VaIN
identify
polypoid mass
embryoyal rhabdoomyosarcoma
identify
botryoides (“grape-like”) polyploid, rounded bulky masses
embryonal rhabdomyosarcoma
identify
“tennis raquet” tumor cells - oval nuclei with ill defined cytoplasm that sometimes extends in a “whisp”
embryonal rhabdomyosarcoma - microscopic
invasive mole
- definition
- clinical characteristics
- a complete hydratiform mole that penetrates/perforates the myometrium
- comes from a complete hydratiform role
- clinical characteristics
- associated with major increased in HcG
- presents with vaginal bleeding and irregular uterine enlargement
partial hydratiform mole
identify picture, note important features
partial hydratiform mole
mixture of small villi and enlarged, proliferating villi (not all villi affected)
central cistern seen
complete hydratiform mole
complete hydratiform mole
scalloped, enlarged villi (all villi affected)
tumors, characteristics
benign serous tumor
- typically unilateral
- morphology:
- gross
- smooth external/internal surfaces
- straw color fluid
- no stroma
- gross
tumor, characteristics
benign serous tumor
- typically unilateral
- morphology:
- microscopic:
- single layer of bland looking (usually ciliated columnar) epithelial cells
- microscopic:
tumor, characteristics
borderline serous tumor
- microscopic- stratification of epithelium (multiple layers)
tumor, characteristics
borderline serous tumor - gross
- microscopic- stratification of epithelium (multiple layers)
- gross
- inc # of papillary projections
- still no stroma
serous tumor (adenocarcinoma)
tumor, characteristics
low grade serous tumor (adenocarcinoma)
- type I carcinomas
- genetics
- wild type p53
- morphology
- extensively papillary
- with MANY psammoma bodies
- some fibrous stroma
- genetics
tumor, characteristics
high grade serous tumor (adenocarcinoma)
- high grade → type II carcinomas
- genetics
- high frequency of p53 mutations
- BRCA-1 & 2 tends to cause these
- morphology
- papillary, inc arcitechtural complexity
- +/- psammoma bodies
- stromal invasion
- genetics
tumor, characteristics
benign mucinous tumor (cystadenoma) - gross
- general characteristics
- almost entirely unilateral
- KRAS mutations are common
- two types: intestinal > endocervical
- metastasis uncommon
- gross: multi-cystic mass with delicate septa
- micro: tall, columnar epithelium without cilia
benign mucous tumor (cystadenoma) - micro
- general characteristics
- almost entirely unilateral
- KRAS mutations are common
- two types: intestinal > endocervical
- metastasis uncommon
- gross: multi-cystic mass with delicate septa
- micro: tall, columnar epithelium without cilia
tumor, characteristics
mucinous borderline tumor - intestinal type (gross)
- gross: multilocular cysts filled with gelatinous contents
- microscopic
- epithelial stratification (multiple layers)
- tufting, budding
general characteristics
- almost entirely unilateral
- KRAS mutations are common
- two types: intestinal > endocervical
- metastasis uncommon
tumor, characteristics
mucinous borderline tumor - intestinal type (gross)
- gross: multilocular cysts filled with gelatinous contents
- microscopic
- epithelial stratification (multiple layers)
- tufting, budding
general characteristics
- almost entirely unilateral
- KRAS mutations are common
- two types: intestinal > endocervical
- metastasis uncommon
endocervical borderline mucinous carcinoma
more rare presentation (intestinal type m/c)
- “papillary heirarchy”
- different than benign tumors d/t inc stratification
krukenberg tumor
- a metastatic tumor
- type of non-mullerian tumor, derived from the GI tract
- m/c non-mullerian tumors are from the GI tract or breast
- (note that metastatic tumors to the ovary - tho - are usually of mullerian origin: uterus, fallopian tube, perionteum, contralateral ovary)
- type of non-mullerian tumor, derived from the GI tract
- presentation:
- gross - bilateral ovary involvement
- microscopic - singlet ring cell
krukenberg tumor
- a metastatic tumor
- type of non-mullerian tumor, derived from the GI tract
- m/c non-mullerian tumors are from the GI tract or breast
- (note that metastatic tumors to the ovary - tho - are usually of mullerian origin: uterus, fallopian tube, perionteum, contralateral ovary)
- type of non-mullerian tumor, derived from the GI tract
- presentation:
- gross - bilateral ovary involvement
- microscopic - singlet ring cell
yolk sac tumor (type of germ cell tumor)- presence of schiller duvall bodies
- seen in children or young women
- for alpha-feto protein
stroma ovarii (type of monodermal or highly specialized teratoma)
- monodermal/highly teratomas
- a type of germ cell tumor
- always unilateral
- most common types are
-
stroma ovariii and carinoid ovarri. both
- can cause hyperthyroidism
- stroma ovarii is made entirely of thyroid tissue (shown in this pic)
-
stroma ovariii and carinoid ovarri. both
dysgerminoma
- most common ovarian malignant germ cell tumor
- is the ovarian counterpart of a testicular seminoma
- bulky, tan lobulated tumors
immature (malignant) cystic teratoma
- type of germ cell tumor
- unlike the mature (benign) cystic teratoma - which is seen in women in reproductive age- this tumor is seen in
- pre-pubertal adolescents and young women (avg age 18)
acute salpingitis: many neutrophils in the MUCOSA
pyosalpinx: dilated fallopian tube FILLED with pus - i.e., lumen filled with neutrophils
chronic salpingitis: neutrophillic infiltate + blunting of villi
chronic salpingitis: neutrophillic infiltate + blunting of villi
hydrosalpinx
- progression from chronic salingitis
- neutrophilic infiltrate has been replaced with CLEAR FLUID
- tube walls - d/t loss of villi - are very smooth instead of folded
hydrosalpinx
- progression from chronic salingitis
- neutrophilic infiltrate has been replaced with CLEAR FLUID
- tube walls - d/t loss of villi - are very smooth instead of folded
tubal (ectopic pregnancy)
- risk factors
- etiology
- morphology
- gross
- microscopic
- sequelae
- biggest risk factor: chronic salpingitis (recall - appearance = neutrophilic lumen + villous blunting)
- etiology: ovum implants into tubal epithelium, then
- chorionic villi, extra-villous trophoblast grow within lumen or into tubal wall, while,
- maternal vessels grow into gestational sac
- morphology:
- gross: hematosalpinx (blood in fallopian tube) d/t maternal vessels → gestational sac
- microscopic: intraluminal chorionic villi & extravillous trophpoblast +/- embryonic parts
- sequelae: tubal rupture → intra-abdominal hemorrhage (life threatening)
ruptured tubal pregnancy
(complication of tubal ectopic pregnancy)
white center: tiny embryo remnant
outer surface of ovary - dusky red & enlarged
tubo-ovarian torsion
cut surface of ovary - hemorrhagic & cystic
tubo-ovarian torsion
