Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Virology > Picornaviruses > Flashcards

Picornaviruses Flashcards

1
Q

What type of genome are picornaviruses

A

Small +ve sense RNA viruses

7.4kb long

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Describe structure of picornaviruses

A

Non-enveloped
30nm in diameter
Composed of 60 protomers forming a symmetrical icosahedral particle
Each protomer is made of 4 proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the celullar receptors for picornaviruses

A

Type 1 glycosaminoglycans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is at the 5’ end of the genome

A

THE IRES

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How do picornaviruses shut down host protein synthesis

A

Viral Protease 2A cleaves the cap structure of mRNA that are needed to initiate synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How many species of enterovises are there

A

13
Enterviruses A-J
Rhinoviruses 1-3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What gene mutant causes less MHC presentation and therefore less B cell destruction

A

IFH1 gene defects

4 variants of this gene reduce the chance of developint T1DM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What % of polio is asymptomatic

A

95%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What % of polio causes CNS infection

A

0.3-1%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the live attenuated polio virus called and what type of immunity does it induce

A

SABIN

IgA mucosal and IgG immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the inactivated polio virus called and what type of immunity does it induce

A

SALK

IgG humoral immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

In 2011 what 4 countries still had a polio epidemic

A

India
Pakistan
Afghanistan
Nigeria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

When was there an outbreak of polio in Nigeria

A

2003

Spread to 8 Polio free countries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What receptors does the rhinovirus access throguh

A

ICAM-1 and LDL receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What % of rhinoviruses are symptomatic

A

2/3

10-20% also get a febirle illness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Name the broad spectrum vaccine that aims to work against enteroviruses and rhinoviruses

A

Pleoconaril

17
Q

What is the link between rhinovirus and asthma

A

90% of children who had a severe rhinovirus infection before the age of 3 had developed asthma by the age of 6

18
Q

What mediates recovery from rhinovirus

A

Unlikely to mediated by Ab or cellular immune response as it takes a week to produce Ab

19
Q

What IgG can cause protection

A

IgA and IgG

IgA appears most important and it decreases after time

20
Q

What do antivirals targeting rhinovirus generally target

A

the capsid

21
Q

what is a problem with antivirals for rhinovirus

A

Problems with optimal administration to the nasal mucosa

22
Q

What % of viral hepatitis worldwide is caused by hep A

A

90%

23
Q

How long is the hep A incubation period

A

2 weeks

24
Q

What is the Ab response rate to the Hep A virus

A

> 95% vaccinees have a protective antibody response by 2-4 weeks

25
Q

What % of people vaccianted with the Hep A virus within 2 weeks of infection can be prevented from getting Hep A

A

85%

Virology (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions