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PI Flashcards

1
Q

PI MOA

A

inhibits HIV-1 protease & rendering the enzyme incapable of cleaving the Gag-Pol polyprotein, resulting in the production of immature, noninfectious virions

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2
Q

PI General Class ADR

A

Lipodystrophy, hyperglycemia, lipohypertrophy, dyslipidemia, Hepatitis, hepatic decompensation, immune reconstitution syndrome, bleeding in pt w/ hemophilia

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3
Q

Reyataz

A

Atazanavir (take w/ food)

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4
Q

Reyataz ADR

A

Kidney stone, prolong PR interval, increase CPK, bilirubin

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5
Q

Prezista

A

Darunavir (take with food)

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6
Q

Prezista ADR

A

Use caution in sulfa allergy pt

Rash (SJS/TEN) may occur

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7
Q

Lexiva

A

Fosamprenavir

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8
Q

Lexiva ADR

A

Use caution in sulfa allergy pt
Rash (SJS/TEN) may occur
Can cause kidney stone

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9
Q

Which PIs can cause kidney stone

A

Lexiva, Crixivan, Reyataz

Lexiva is a Renal (Reyataz) Criket (Crixivan

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10
Q

Crixivan

A

Indinavir

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11
Q

Crixivan ADR

A

kidney stone, stay hydrated

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12
Q

Viracept

A

Nelfinavir

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13
Q

Viracept ADR

A

Explosive diarrhea

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14
Q

Norvir

A

Ritonavir (booster)

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15
Q

Norvir ADR

A

Increase CPK, uric acid & cause prolong PR interval

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16
Q

Kaletra

A

Lopinavir + Ritonavir

17
Q

Kaletra ADR

A

pancreatitis (sometimes fatal)

Prolong PR interval

18
Q

Invirase

A

Saquinavir

19
Q

Invirase contraindication

20
Q

Aptivus

A

Tipranavir

21
Q

Aptivus BBW

A

Hepatitis

Fatal & nonfatal intracranial hemorrhage

22
Q

PIs contain sulfa

A

Aptivus, Lexiva, Prezista

HIV (6 decks)

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