NNRTIs

Question 1

NNRTIs MOA

Answer 1

bind to reverse transcriptase & block the RNA-dependent & DNA-dependent DNA polymerase activities in HIV-1 replication

Question 2

NNRTIs General Class ADR

Answer 2

Rash (SJS/TEN) sometimes severe (most common with Viramune), increase LFTs, GI upset

Question 3

Rescriptor

Answer 3

Delavirdine

Question 4

Rescriptor ADR

Answer 4

Rash, GI upset, headache, increase LFTs

Question 5

Rescriptor CI

Answer 5

Alprazolam, ergot, midazolam, pimozide, rifampin, triazolam

Question 6

Sustiva

Answer 6

Efavirenz

Question 7

Sustiva ADR

Answer 7

Vivid dream, drowsiness, impaired concentration, depression, mania, suicide (CNS)
Take on empty stomach at bedtime

Question 8

Atripla

Answer 8

Efavirenz + Emtricitabine + Tenofovir

Pregnancy D

Question 9

Intelence

Answer 9

Etravirine

Question 10

Intelence ADR

Answer 10

Rash, peripheral neuropathy, nausea, HTN

Question 11

Viramune

Answer 11

Nevirapine

Question 12

Viramune BBW

Answer 12

Severe hepatotoxicity reaction may occur (liver failure, death) may occur 1st 6 wks
Severe, life-threatning skin reaction (SJS, TEN)

Question 13

Viramune ADR

Answer 13

Rash, increase LFT, GI upset

Question 14

Rilpivirine

Answer 14

Edurant

Question 15

Complera

Answer 15

Rilpivirine + Emtricitabine +Tenofovir

Rilpivirine is an Edurant Triathlon (Tenofovir) Completes (Complera) the race

Question 16

Edurant CI

Answer 16

3A4 inducers, PPIs, ok w/ H2RA (12hrs before or 4 hrs after), antacids 2 hrs before or 4 hrs after