Integrase Inhibitor

Question 1

MOA

Answer 1

Block the integrase enzyme needed for viral DNA to enter into the host nucleus
Isentress is only reserved for pt with HIV-resistant not naive pt

Question 2

Isentress

Answer 2

Raltegravir 400 mg BID

Take w/o food regard to meal

Question 3

Isentress ADR

Answer 3

Most common is diarrhea, nausea, headache

Can increase CPK and cause myopathy & rhabdomyolysis (with statin use)