Physiology of tooth movement and appliances overview Flashcards
What is the Physiological basis of orthodontics?
- If external force applied to tooth, tooth will move as bone around it remodels
- Bony remodelling is mediated by periodontal ligament
- If tooth has no PDL or is ankylosed will not move
- Cementum more resistant to resorption than bone
- Some degree of root resorption after orthodontics should be expected
What are the 3 theories for orthodontic tooth movement?
- Piezo-electric theory
- Differential pressure theory
- Mechano-chemical theory
What is the differential pressure theory?
- Coronal part of tooth undergoes a force
- Root undergoes compression and tension
- In areas of compression bone is resorbed
- In areas of tension bone is deposited
What is the mechano-chemical theory?
- Occurs at cellular level
- Cell shape changes occur within periodontal ligament and adjacent alveolar bone
- Inititiates signalling interactions between cells e.g. Production and release of cytokines
What are cytokines?
- Low molecular weight proteins
- Regulate action of target cells
- May cause target cells to secrete mediators
- Lots of cytokines within PDL
What is the mechano-chemical theory?
- Occurs at cellular level
- Cell shape changes occur within periodontal ligament and adjacent alveolar bone
- Initiates signalling interactions between cells e.g. Production and release of cytokines
Histologically how is the periodontal space maintained?
- On root surface the cementum covered by cementoblasts
- Sharpey’s fibres (collagen fibres) penetrate cementoblasts and attach to cementum
- In PDL epithelial cells islands form 3D network around root (called Epithelial Rests of Malassez)
- Epithelial Rests of Malassez constantly release Epithelial Growth Factor (EGF)
- EGF diffuse through cells in extracellular matrix and stimulate osteoclasia on periodontal bone surface
- Promotes maintenance of periodontal space
What is the mechanism for bone resorption in the mechano-chemical theory?
- Mechanical loading
- Fluid movement, stretching and compression of fibres within PDL ; lead to 1,2,3,4
- Adjacent bone distorted
- Fluid flow within bone canaliculi is altered
- Osteocytes within bone detect distortion
- Osteocytes produce cytokines
- Cytokines activate osteoblasts to recruit osteoclasts
- Bone resorption
- Adjacent bone distorted
- Macrophages increase production of IL-1
- Bone resorption - Osteoblasts produce prostaglandins and leukotrienes
- Bones resorption - Fibroblasts produce Matrix metalloproteinases
- Bone resorption
What is the cascade of cytokines within the periodontal ligament leads to bone resoprtion?
- Cytokines activate osteoblasts to produce Prostaglandins (PGE-2) and leukotrienes
- PGE-2 and leukotrienes causes osteoblasts to produce intracellular messenger (secondary messenger)
- Intracellular secondary messengers initiate production of Receptor Activator of Nuclear factor Kappa-B-Ligand (RANKL) and CSF and IL-1
- IL-1 increases production of RANKL
- RANKL and CSF cause blood monocytes to fuse and form multinucleated osteoclasts
- RANKL stimulates osteoclast to become active and resorb the bone
How are osteoblasts involved in areas of compression?
- Osteoblasts bunch together
- They expose the osteoid layer giving osteoclasts access to resorb the bone
- Osteoblasts send signals to osteoclasts (e.g. RANKL) to recruit and activate osteoclasts to resorb bone
How are osteoblasts involved in areas of tension?
- Osteoblasts are flattened covering the osteoid layer
- Prevents osteoclasts from gaining access to the bone
- Osteoblasts secrete collagen and other proteins forming the organic matrix
- Secrete Hydroxyapatite crystals which form new bone into the organic matrix
What two components are viral in regulating bone remodelling?
- Osteoblasts release another protein called Osteoprotegerin (OPG) which prevents osteoclastic differentiation and suppresses their activity
- Balance between RANKL and OPG produced regulates bone remodelling
How do orthodontists use this knowledge to their advantage?
- Utilise the inflammatory response which occurs in PDL when a force is placed on teeth
- Use appliances to transmit force to PDL and bone
- Manages patients carefully through periods of resorption and repair of their alveolar bone
What are the types of orthodontic appliances?
- Removable (URA)
- Functionals
- Fixed
What are the types of tooth movement?
- Tipping
- Bodily movement
- Intrusion
- Extrusion
- Rotation
- Torque