Physiology of labour Flashcards
Define parturition
Labour and childbirth
What is meant by placental clock?
Predestined lifespan of placenta is up to 42 weeks. After this, reduced release of progesterone from placenta and function decreases
What is meant by the foetal clock?
Baby starts producing oestrogen therefore baby is main decided of when labour begins. Oestrogen produced by adrenal glands in the foetus
Easy way to remember if prostaglandin dilates or contracts?
Vowel= dilator Consonant= contractor
What prostaglandins do oestrogens predominantly make?
F and C (contractor)
What prostaglandings do progesterones predominantly make?
E and I (dilators)
What is cervical ripening?
Cervix changes from cylinder to small circle
Becomes soft and pliable
Mediated by collagenolysis
What is myometrial ripening?
Increased cell to cell adhesion and more production of gap junctions
Causes increased oxytocin receptor expression at fundus
What is the main drive for myometrial ripening
Oxytocin
Prostaglandins enhance this change
What is Ferguson’s reflex?
Oxytocin release in circulation, arrives at fundus
Triggers myometrial contraction
Cranial–> caudal contraction, baby pushed further into cervix
Stretch of cervix causes further increase in oxytocin so more contractions
3 signs of labour
Membrane rupture
The show- release of mucus plug which seals cervix
Painful contractions (lasting >40 seconds and come closer and closer)
What is the danger of a baby that doesn’t deliver 24 hours after membrane rupture
Bacterial infection
Why is backache a symptoms of labour?
Innervation of cervix comes from S3-S4 so stimulates nerve endings in the back
What happens in the first stage of labour?
Cervix effaced and dilates from 0-10cm
Myometrial fibres contract and retract
Upper segment of uterus becomes heaped up whilst lower part passivelt thins
How is first stage of labour divided?
Latent phase: 1-3cm dilation
Active phase: 3-10cm dilation