Physiology: Male and Female Flashcards
What are the components of female reproductive physiology?
- HPO axis
- Ovarian cycle
- Menstrual cycle
- Hormones
What is GnRH?
Gonadotrophin releasing hormone
What are the female gonadotrophins?
- FSH (follicle stimulating hormone)
- LH (luteinising hormone)
What steroid hormones are involved in the female reproductive system
- Oestrogen (Oestroadiol, oestrone, oestriol)
- Progesterone
- Testosterone
What is the Hypothalamo-pituitary-ovarian axis?
- Hypothalamus releases GnRH which acts on pituitary gland
- Pituitary gland release FSH and LH which act on the ovaries
- Ovaries release ova , progesterone and oestrogen
What are the 2 functions of the ovary?
Production of eggs and production of steroid hormones
What type of feedback does oestrogen have on the anterior pituitary and hypothalamus?
- Negative for most of the cycle
- Positive (day 12-14) in response to LH surge
How is a new cycle started?
FSH and LH initiate the growth of new ovarian follicles, beginning a new cycle
What is the follicular phase of the ovarian cycle concerned with?
Follicular growth
-The development of a single follicle for egg release
What is the luteal phase of the ovarian cycle concerned with?
Maturation of the corpus luteum
What does the corpus luteum produce?
Progesterone
What effect does progesterone have on the uterus?
Causes pregnancy changes to occur such as thickening of the wall of the uterus
What are the phases of the menstrual cycle?
- Menstrual phase (0-4)
- Proliferative phase (4-14)
- Secretory phase (14-26)
- Premenstrual phase(26-28)
When in the menstrual cycle do hormones level drop?
Around day 26 if no pregnancy is detected
What are the stages of oogenesis?
- Oogonium forms primary oocyte
- Undergoes 1st meiotic division to form secondary oocyte and polar body
- Secondary oocyte undergoes 2nd meiotic division to form ovum and polar body
- Ovum becomes mature egg cell
What are oogonium?
Stem cells in the ovary