Physiology Flashcards
Give Ohms Law
V = IR
Give Ohms Law for ion channels
I = GV
where G is conductance
What is the EQLpt for sodium?
ENa = +60 mV
A NAg counts seconds to 60 A nag (Sodium) counting to 1 minute before saying anything is good news
What is the EQLpt for potassium?
EK = -90 mV
A King will die at 90
When the king (potassium) dies, it is negative
What is the EQLpt for calcium?
ECa = +123 mV
A CAt is as easy as 1-2-3
Easy things are positive; so are cats (Calcium)
What is the EQLpt for chlorine?
ECl = -40 mV
A CLub for fighting Ali Baba’s 40 thieves
Fighting Ali Baba’s 40 thieves in their CLub all at once is quite scary (negative)
What is the resting potential for neurons?
-70 mV
What is the function of tropomyosin?
to block myosin binding sites on actin molecules
this prevents cross-bridge formation, which prevents contraction in a muscle without nervous input
the protein complex troponin binds to tropomyosin, helping to position it on the actin molecule
What are the three subunits of Troponin?
TnI
TnC
TnT
What is the function of TnI?
to connect to the thick filament/actin
How does TnC work?
undergoes a conformational change when it binds to calcium
binds to TnT (and TnI)
What is the function of TnT?
binds to tropomyosin
can pull tropomyosin out of actin’s active myosin-binding site
How many G-actin monomers are there per turn of helix?
7
What does SERCA stand for?
Sarcoendoplasmic reticulum calcium transport ATPase
What’s Donepezils role functionally?
acts as a centrally acting reversible acetylcholinesterase inhibitor
