PHYSIOLOGY Flashcards

1
Q

what is the epithelium called that produces cerebrospinal fluid (CSF)

A

choroid plexus secretory epithelium

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2
Q

name all the places where CSF production occurs (5)

A
lateral ventricles
3rd ventricles 
4th ventricles 
subarachnoid space 
circumventricular organs
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3
Q

how much CSF is made in a day

how much CSF can the CNS hold

how many times is CSF replaced per day

A

600ml

150ml

replaced 4 times every day

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4
Q

what is the CSF mainly made of

what other 2 things are there in it (but not in significant amounts)

A

water

proteins
immunoglobulins

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5
Q

where does CSF production start

A

lateral ventricles (anterior, inferior and posterior horns)

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6
Q

where does CSF go after lateral ventricles

A

3rd ventricle

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7
Q

where does CSF go after 3rd ventricle

A

4th ventricle

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8
Q

where does CSF go after 4th ventricle

A

subarachnoid space

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9
Q

where does CSF go after subarachnoid space

A

reabsorbed into dural venous sinuses (venous blood)

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10
Q

where is the subarachnoid space between

A

pia and dura matter

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11
Q

what is the function of CSF

A

to exchange things between blood and brain tissue (eg water, amino acids, ions, removes metabolites)

buoyancy for brain (it floats in it) = shock absorption to protect it

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12
Q

how can you obtain CSF

where specifically

A

lumbar puncture at L3/4 or L4/5 (no spinal cord nerves here)

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13
Q

by which embryological process are the choroid plexuses made

A

invagination

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14
Q

what is the connection between the lateral ventricles and the 3rd ventricle

A

interventricular foramina of munroe

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15
Q

what is the connection between the 3rd and 4th ventricles

A

cerebral aqueduct of sylvius

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16
Q

what is the connections between the 4th ventricle and the subarachnoid space

A
median aperture (foramen of magendie)
2 lateral apertures (foramen of luschka)
17
Q

how does CSF move from subarachnoid space to dural venous sinuses

A

arachnoid granulations

18
Q

what is rhodopsin made of

A

retinal (vit A derivative) and opsin

19
Q

what happens when light interacts with rhodopsin

A

splits into retinal (all-trans-retinal) and opsin

20
Q

what happens to all-trans-retinal after its been converted from rhodopsin

A

turns into all-trans-retinol

21
Q

what is all-trans-retinol the same as

A

vitamin A

22
Q

in the presence of light rhodopsin splits back into all-trans-retinal and opsin, what does the opsin cause

A

decreased cGMP = Na channels close = hyperpolarisation = decreased membrane potential = high glutamate

23
Q

where do you get rhodopsin

A

rods

Rhodopsin = Rods