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Step 1: Musculoskeletal > Physiology > Flashcards

Physiology Flashcards

1
Q

Calcium efflux from myocytes

A

Na+/Ca2+ exchange pump and sarcoplasmic reticulum Ca2+-ATPase pump

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2
Q

How does calcium influx lead to muscle contraction?

A
  1. Voltage gated Ca2+ channel opens –> calcium-calmodulin complex activates Myosin light chain kinase which phosphorylates Myosin
  2. Calcium binds troponin on actin –> moves tropomyosin out of the way –> exposes myosin binding site
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3
Q

What is the role of ATP in muscle contraction?

A

Causes Actin-myosin to detach –> When ATP is split the myosin head is cocked and readied for next contraction

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Step 1: Musculoskeletal (6 decks)

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