Physiology 4

Question 1

Describe the change in oxygen partial pressure around the system

Answer 1

From atmosphere to lungs partial pressure decreases and further slight decreases occur as oxygen travels through the system

Question 2

Effect of partial pressure on gas solubility - Henry’s law

Answer 2

Increase in partial pressure increases gas solubility

Question 3

Ways oxygen is transported in the blood

Answer 3

(1) most - Haemoglobin bound oxygen (Rev blood cells)

(2) fewer - oxygen physically dissolved in blood

Question 4

What is the primary factor which determines percent saturation if haemoglobin with O2?

Answer 4

Oxygen partial pressure (PO2)

Question 5

Oxygen delivery to tissues can be impaired by…

Answer 5

Respiratory disease
Heart failure
Anaemia

Question 6

Co-operative of haemoglobin binding to O2

Answer 6

Binding of one subunit increases affinity for other subunits
(Sigmoid curve - flattens once all sites occupied)

Question 7

Bohr effect - PO2 in arterial blood vs tissues

Answer 7

PO2 higher in Arterial blood > more O2 picked up

PO2 lower in tissues > encourages release of O2

Question 8

Foetal haemoglobin HbF

Answer 8

Higher O2 affinity - allows transfer of O2 between mother /foetus if O2 levels are low

Question 9

Where is Myoglobin (Mb) round and how many hawk groups does it have?

Answer 9

Only present in skeletal and cardiac muscle, has 1 harm group > no co-operativity

Question 10

Presence of myoglobin in blood indicates…

Answer 10

Muscle damage