Physiology

Question 1

Where do B cells mature?

Answer 1

periphery

Question 2

Where to T cells mature?

Answer 2

thymus

Question 3

What does the common lymphoid progenitor give rise to?

Answer 3

T, B, NK cells

Question 4

What does the common myeloid progenitor give rise to? (4)

Answer 4

Megakaryocytes
Erythrocytes
Dendritic cells
The granulocyte + macrophage progenitor

Question 5

What does IL6 do in the BM?

Answer 5

Promotes growth + development of T & B lymphocytes

Question 6

Which interleukins are important in BM?

Answer 6

IL1, IL3, IL6, GM-CSF

Question 7

What are granulocytes?

Answer 7

WBC with many granules

Question 8

Which cells are considered granulocytes?

Answer 8

Neutrophils
Eosinophils
Basophils

Question 9

Which cells are considered antigen presenting cells?

Answer 9

Dendritic cells
Monocytes
Macrophages
B cells

Question 10

Which cells are considered lymphocytes?

Answer 10

T cells, B cells, NK cells

Question 11

What is the role of a neutrophil?

Answer 11

Move to site of infection, phagocytose and kill via oxidative pathway

Question 12

Which interleukin activates eosinophils in setting of allergy?

Answer 12

IL5

Question 13

What is the major growth factor for lymphocytes?

Answer 13

IL2

Question 14

What gene is known to be important for T cell receptor development? (if absent = SCID)

Answer 14

RAG gene

Question 15

In which HLA class can CD8 cells recognise antigen?

Answer 15

MHC class I

Question 16

In which HLA class can CD4 cells recognise antigen?

Answer 16

MHC Class II

Question 17

What do Th1 cells promote? (T-helper sub-set)

Answer 17

Cell mediated immunity

Question 18

What do Th2 cells promote?

Answer 18

Humoral immunity (via IL5/6)

Question 19

What receptor has to be stimulated for B cell class switching to occur?

Answer 19

CD40 ligand receptor

Question 20

From what source does the MHC Class I molecule present antigen?

Answer 20

Intracellular sources (endogenous peptides)
- tumours, viruses, bacteria

Question 21

From what sources does the MHC Class II molecule present antigen?

Answer 21

Extracellular sources (exogenous peptides)
- bacteria + killed viruses

Question 22

On what cells are MHC Class I molecules expressed on?

Answer 22

ALL nucleated cells in the body

Question 23

On what cells are MHC Class II molecules expressed on?

Answer 23

APCs

Question 24

What does the term humoral immunity refer to?

Answer 24

Production of specific antibody against pathogen (B cells)

Question 25

What does the term cellular immunity refer to?

Answer 25

T cell dependent macrophage activation (T cells)

Question 26

What do CD4 T cells do?

Answer 26

Activate macrophages and class switching

Question 27

What is the classical complement pathway triggered by?

Answer 27

IgG, IgM