Complement deficiencies Flashcards
1
Q
What type of infections does an anomaly of the classical pathway predispose patients to?
A
Encapsulated bacterial infections
2
Q
What does a deficiency of the Membrane Attack complex predispose patients to?
A
Neisseria infections
3
Q
What does a deficiency of C1 esterase cause?
A
hereditary angio-edema
4
Q
How is hereditary angioedema inherited?
A
AD
5
Q
What complement proteins comprise the classical pathway?
A
C1, C2, C4
6
Q
What is the classical pathway activated by?
A
C1q, CRP
7
Q
Which complexes in the complement cascade form the membrane attack complex?
A
C5a - C9
8
Q
What is the main inhibitor of the complement cascade?
A
C1 esterase
