Physiology. Flashcards
What are the two divisions of the autonomic nervous system?
Sympathetic and Parasympathetic.
What are the two systems of the somatic nervous system?
Motor and sensory.
What is the submucous plexus?
Sensory neurons that detect changes in chemical environment.
What is the myenteric plexus?
Motor/motility of GIT.
What is noradrenaline?
Excitatory neurotransmitter of postganglionic sympathetic neurons.
What is acetylcholine?
The excitatory neurotransmitter of postganglionic sudomotor (has to do with sweat glands) neurons.
What tissues are co-innervated by both sympathetic and parasympathetic?
Heart.
GIT.
Cranial vessels.
What tissues are only sympathetic?
Skin and vessels.
What are some sympathetic system features?
Increase heart rate.
Increase the force of contraction.
Vasoconstriction.
What are some parasympathetic system features?
Decrease heart rate.
Vasodilation.
Pupillary constriction.
What are some sympathetic system hormones?
Epinephrine, norepinephrine.
What is the parasympathetic system hormone?
Acetylcholine.
Epinephrine/Adrenaline acts on which type of receptors?
Alpha 1 - Vasoconstriction.
Beta 1 Positive Effect.
Beta 2 Vasodilation.
Norepinephrine acts on which type of receptors?
Only on Alpha 1 and Beta 1.
When is the vasoconstrictive drive increased?
In Heart failure, essential hypertension, metabolic syndrome and COPD.
What is sympathectomy?
Removal of sympathetic ganglia at T2-T4 - results in palmar hyperhidrosis (interrupts sympathetic outflow).
Acetylcholine is the excitatory neurotransmitter at which synapses?
Nicotinic and muscarinic synapses.
What do postganglionic sympathetic neurons release?
Noradrenaline (adrenergic receptors).
What do parasympathetic postganglionic neurons release?
Acetylcholine (muscarinic receptors).
What do neurons generate?
A negative potential called the resting membrane potential.
Where is the action potential propagated?
It is propagated along the length of the axon.
Electrical signals arise from what?
Ion fluxes - when a cell membrane is being selectively permeable.
What is an All-or-none response?
The strength of the stimulus does not matter. If above threshold, nerve/fibre will fire.
What do we know about fibre diameter?
The greater the diameter, the faster the AP spreads.
What do we know about myelination?
Myelinated nerves conduct faster.
What are some features of myelin?
Less leakage.
Less Na.
Saltatory conduction at nodes of ranvier.
What is multiple sclerosis?
Autoimmune disease.
Damaged myelin.