Physiology 12.13.12 Circulation through Individual Tissue Beds Flashcards
Is sympathetic tone always present in coronary circulatino
yes
What changes the flow to heart
local metabolites produced by working msucle
Blood flow is proportional to what
Rate of work
Is flow slowed or increased during contraction of heart
slowed
What is ht mL/min of coronary blood flow at rest
250 mL/min
What % of coronary blood flow supplies left heart? right heart?
80% left heart
remainder ot right heart
What % of CO is coronary blood flow at rest
5%
Where do the major coronary arteries arise form?
Aorta distal to aortic valve
and provide virtually all the arterial blood supply
Describe the venous drainage of the myocardium
Coronary capillary blood flows via venules to veins that reach epicardial surface of heart and parallel teh arterial supply back to Coronary sinus
How do most of hte left ventricular capillary blood reach the right atrium
by wa of coronary sinus
small portion (of right ventricle capillaries) reaches right atirum by way ANTERIOR CARDIAC VEIN
What are thesbian veins
how inconsequential amt of blodo reaches cardiac ventricels direclty
What are factors that influence coronary blood flow
Aortic Pressure during Diastole
Extravascular Compression (squeezing of vessels during systole)
Sympathetic effects
Metabolic Factors
Coronary BF and Aortic P
Aortic P provides DF for BF through coronary arteries
During Diastole, flow is direclty proportional to aortic pressure
Severe hypothension (shock) and Coronary BF
Low aortic P may limit coronary BF
Increase in mean aortic P during exercise
increased ocronary BF
Extravascualr compression (squeezing) of myocardial vessels
occurs during cardiac systole
Compression reduces vascular diameter –> Increase vascular resistance –> decreases flow
What can happen during isovolumentric contraction of left ventricle
Extravascular compression is so great that flow in the left coronary artery may reverse momentarily
When is extravascular compression a problem
with sustained hypertension
Elevated afterload on LV increases ventriuclar work and O2 demand while also increasing extravascular compression
Combo increses the need for blood flow and restricts it as well
During conditions with reduced BF to heart (coronary occlusion or hypotension) is damage more likely to the inner (endocardial) wall of ventricle or outer (epicardial) wall
Inner Endocardial Wall
b/c extravascular compression is more significant
Does extravascular copression disturb coronary flow in right ventricle
not as much bc myocardial pressure is not nearly as reat
Total flow in right coronary artery is actually greater during systole than diastole b/c of greater driving pressure during systole
Sympathetic effect on coronary blood flow
Stimulation of sympathetic nerves to heart increases BF indirectly
In normal circumstances, sympathetic stimulation increases coronary BF by increasing HR and contractility whih increases Cardiac worka nd Myocardial O2 consumption
The resuling decerase in tissue O2 increases coronary BF by METABOLIC REGULATION
What happens if inotropic and chornotorpic effects of smpahteric stimulation are inhibited by beta adrenergi blocker
symp stimu decreases BF suggestion that alpha adrenergic vasoconstriction of cornoary vessels has occurred
What metabolites are implicated in metabolic mechainism which O2 demands triggers coronary vasodilation
H+ lactic acid Co2 Adenosine Endothelial derived relaxing factor (NO) K+
The more oxygen consumed, the more coronary blood flow
What happens during progressive ischemia (causing hypoxia) of myocardial tissue
stiualtes growth of colalteral vessels allowign more blood (O2) to reach ischemic area
Severe ischemia of cardiac tissue gives rise to chest pain (angina pectorsi)
What can releive angina
adminitstration of nitrites (nitroglycerin or ayl nitrite)
Gives rise to NO, acts as systemic vasodialtors, esp dilating coronary arterioles – .decreaseing afterload against whcih LV works
THis decreases myocardial O2 deman ,relieves myocardial ypoxia and angina
What is the O2 consumption in the non-exercising invididual
8-10 ml/min/100g of heart
Even at rest the herat is owrking