Physiology Flashcards
WHAT IS HOMEOSTASIS
Maintenance of nearly constant conditions in the internal environment.
what is internal environment
extracellular fluid or interstitial fluid
difference between ICF and ECF
ECF
14 L
Large amount of Sodium, chloride and bicabonate ions.
Oxygen and carbon dioxide.
Nutrients: Glucose, fatty acids and amino acids.
ICF
28 L
Potassium, magnesium and phosphate
why is ECF called internal environment
ECF has ions & nutrients needed by the cells to maintain cell life.
All cells live in essentially the same environment (ECF).
ECF = internal environment / milieu interieur
Cell growth & functions depend on proper concentration of components of internal environment (oxygen, glucose, different ions, amino acids, fatty substances etc..
how many times the blood circulate in one minute
At rest:
1 rotation / minute.
Extreme activity:
6 rotations / minute
define feedforward
term used for responses made in anticipation of a change
define feedback and name its type
Refers to responses made after change has been detected
Types of feedback systems
Negative
Positive
what are examples of negative feedback
Higher conc. of CO2 in ECF Increase in pulmonary ventilation more expiration of CO2 decrease in CO2 conc. in ECF.
High blood pressure series of reactions lower pressure OR
Low blood pressure series of reactions higher pressure.
Both the effects are negative to the initiating stimulus.
Thus homeostasis is maintained to prevent excess or deficiency of substances internal environment (ECF) is kept constant.
give example of positive feedback resulting in death
Normal heart pumps 5L/min.
2L Bled person poor pumping, less arterial pressure, less coronary flow weak heart less pumping, further less coronary flow more weak heart death.
Conclusion: Initiating stimulus causes more of the same (positive feed back).
Mild positive feedback may not lead to death, if overcome by negative feedback control (e.g., if person bled 1L Control mechanisms recovery).
describe positive feedback as part of a negative feedback mechanism
Rupture of blood vessel formation of clot activation of clotting factors / enzymes within the clot.
Some of these enzymes activate enzymes of adjacent blood more blood clotting till plugging of hole bleeding stops.
Sometimes unwanted clots formation atherosclerotic plaque in coronary artery acute heart attack.
describe positive feedback mechanism associated with childbirth
Strong uterine contractions during childbirth baby’s head pushed through cervix stretch of cervix signals through uterine muscle body of uterus more powerful contractions more stretch to cervix more stronger contractions.
If strong enough baby is born.
If not strong enough contractions die out restart after few days.
describe and relate feedforward control and adaptive response
When there is not enough time for afferent signals (from periphery to brain) & efferent nerve signals (from brain to periphery) sensory nerve signals from moving parts apprise the brain, whether movement is performed correctly (FEED FORWARD CONTROL)
If not brain corrects feed forward signals in the next attempt of muscle contraction.
If further correction is required done in subsequent contractions (ADAPTIVE CONTROL / DELAYED NEGATIVE FEEDBACK).
describe cytoskeleton nd its components
Cytoskeleton, a system of fibers that not only maintains the structure of the cell but also permits it to change shape and move.
Microtubules
Intermediate filaments
Microfilaments
describe the structure of microtubules in cell
Uniform in size and straight.
25nm in diameter and several micrometers in length.
Wall of microtubules consists of individual filamentous structures made of protein tubulin.
what are the functions of microtubules
They are considered to be a framework that determines the shape of the cell.
They are involved in transport of macromolecules in the cell’s interior.
Several cell organelles are derived from special assemblies of microtubules.
Cilia, flagella, basal bodies and centrioles have groups of microtubules arranged in a special fashion.
Mitotic spindles are also composed of microtubules
describe strcuture and function of microfilaments
Microfilaments represent the active or mobile part of cytoskeleton.
These are the thinnest, ranging in diameter from 6 to 7 nm.
Composed of protein actin, myosin, as well as tropomyosin and other proteins.
Actin filaments are made of globular actin molecules, called G-actin.
They help generate movement (muscle contraction, cell division and cell locomotion) and provide mechanical support to cell.
describe types and function of intermediate filaments
Found in parts of cells subject to mechanical stress, help stabilize the position of organelles such as nucleus & help attach cells to one another.
Keratin filaments, present in epithelial cells.
Neurofilaments, present in axons, dendrites.
Glial filaments, present in astrocyte.
Heterogenous filaments, e.g., desmin and vimentin filaments.
what are the functions of cytoskeleton
Plays an important role in maintaining the cell shape.
Cytoskeletal fibers stabilize the positions of organelles.
Cytoskeleton helps transport materials into the cell and within cytoplasm.
Fibers of cytoskeleton connect with protein fibers in the extracellular space, linking cells to each other and to support material outside the cells.
Cytoskeleton enables cell movement
describe structure and structural components of cilia
Cilia are short, hair like structures projecting from the cell surface like the bristles of brush.
Surface of cilium is continuation of cell membrane, and its core contains nine pairs of microtubules surrounding a central pair.
Multiple protein arms composed of protein dynein, having ATPase activity, project from tubules.
Microtubules terminate just inside the cell at basal body. Or cilium is an outgrowth of basal body.
Basal body is similar in structure to centriole.
what are the functions of cilia
Cilia beat rythmically back and forth
Ciliary movement creates currents that sweep fluids or secretions across the cell surface.
Ciliary movement is a whip like movement that occurs in only 2 places in human body: on the inner surfaces of respiratory airways and on the inner surfaces of uterine tubes (fallopian tubes).
In resp. airways, movement of cilia causes a layer of mucus to move towards pharynx.
In uterine tubes, it moves ovum towards uterus.
what are functions and functional elements of flagellum
Function of flagellum is to push the cell through fluid with wave like movements, just as undulating contractions of a snake’s body.
Axoneme is the term applied to axial structure of cilia and flagella, and is the essential motile element.
There are 2 conditions for continuous beating of axoneme: presence of ATP and appropriate ionic conditions, especially calcium and magnesium
describe ameboid movement
It means movement of an entire cell in relation to its surroundings. For example, movement of WBC’s through tissues.
This movement begins with protrusion of pseudopodium from one end of the cell and attaches to a new area of tissue.
Remaining cell is pulled toward pseudopodium.
what is the mechanism of ameboid movement
It results from formation of new cell membrane continuously at the leading edge of pseudopodium and continuous absorption of membrane in remaining parts of cell.
Attachment of pseudopodium to surrounding tissues occurs while remaining cell is pulled forwards towards the point of attachment.
Attachment is caused by receptors present in exocytotic vesicles.
Vesicles become part of pseudopodial membrane and they open to exterior.
This exposes the receptors which now attach to surrounding tissues.
At the opposite end of cell, receptors pull away from their ligands, forming endocytotic vesicles.
These vesicles move toward pseudopodial end, where they are used to form new membrane for pseudopodium.
Energy is required for all this mechanism.
Protein actin is present in cytoplasm of all cells.
Actin network binds with another protein, myosin thus causing contraction.
Whole process is energized by ATP.
what is the intercellular gap between epithelium and other closely packed tissues
20nm