Physiological Systems Flashcards

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1
Q

What are the main glands of the Endochrine System?

A

Pineal gland, Hypothalamus, Pituitary gland, Parathyroid gland, Thyroid gland, Thymus, Adrenal gland, Pancreas, Ovary, Testes

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2
Q

Although poorly understood, what is the main known function of the Pineal gland?

A

Production of Melatonin, responsible for sleep regulation

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3
Q

What are the main functions of the Hypothalamus?

A
Modulation of: body temperature,
thirst,
appetite and weight control,
emotions,
sleep cycles,
sex drive,
childbirth,
blood pressure and heart rate via the release of;
 corticotrophin-releasing hormone, dopamine, growth hormone-releasing hormone, somatostatin, gonadotrophin-releasing hormone and thyrotrophin-releasing hormone.
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4
Q

What 8 hormones are controlled by the Pituitary Gland and what are their functions?

A

ACTH: Adrenocorticotrophic hormone. Stimulates the production of cortisol, a “stress hormone” that maintains blood pressure and blood sugar levels.
FSH: Follicle-stimulating hormone. Promotes sperm production and stimulates the ovaries to produce estrogen.
LH: Luteinizing hormone. Stimulates ovulation in women and testosterone production in men.
GH: Growth hormone. Helps maintain healthy muscles and bones and manage fat distribution.
PRL: Prolactin. Causes breast milk to be produced after childbirth. It also affects hormones that control the ovaries and testes, which can affect menstrual periods, sexual functions and fertility.
TSH: Thyroid-stimulating hormone. Stimulates the thyroid gland, which regulates metabolism, energy and the nervous system.
Oxytocin: Helps labor to progress, causes breast milk to flow, affects labor, breastfeeding, behavior and social interaction and the bonding between a mother and child.
ADH: Anti-diuretic hormone, or vasopressin. Regulates water balance and sodium levels.

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5
Q

What is the function of the parathyroid gland?

A

It regulates blood calcium levels

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6
Q

What is the function of the Thyroid gland and what hormones are involved?

A

Helps regulate the body’s metabolism via the production of triiodothyronine and thyroxine

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7
Q

What is the main function of the Thymus?

A

The thymus is a specialized primary lymphoid organ of the immune system. Within the thymus, thymus cell lymphocytes or T cells mature.

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8
Q

What is the function of the Adrenal gland and what hormones does it produce?

A

Adrenal glands produce adrenaline and the steroids aldosterone and cortisol that help regulate your metabolism, immune system, blood pressure, response to stress and other essential functions

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9
Q

What are the functions of the Pancreas?

A

During digestion, your pancreas makes pancreatic juices called enzymes. These enzymes break down sugars, fats, and starches. Your pancreas also helps your digestive system by making hormones

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10
Q

What hormones are produced in the Ovaries and what are their functions?

A

The major hormones secreted by the ovaries are oestrogen and progesterone, both important hormones in the menstrual cycle

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11
Q

What hormones are produced by the Testes?

A

The main hormone secreted by the testes is testosterone, an androgenic hormone.

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12
Q

What four levels make up the hierarchy of complex organisms?

A

Specific types of cells are grouped together to become Tissues (bone tissue, muscle tissue etc).

Tissues can be grouped together to form organs (liver, heart, lung, etc).

Organs can be grouped together to form systems. (Cardiac system etc).

These systems interconnect to maintain the health of their own and other organs.

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13
Q

What 5 organelles make up the basic cell anatomy?

A

Nucleus, Ribosomes, Cytoplasm, Cell membrane, Mitochondria

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14
Q

What is the function of the Nucleus of a cell?

A

To control gene expression and mediate the replication of DNA during the cell cycle

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15
Q

What is the function of a Ribosome?

A

Ribosomes are minute particles consisting of RNA and associated proteins that function to synthesize proteins.

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16
Q

What is the function of the Cytoplasm?

A

Liquid that fills the inside of a cell. It is composed of water, salts, and various organic molecules. Some intracellular organelles, such the nucleus and mitochondria, are enclosed by membranes that separate them from the cytoplasm.

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17
Q

What is the function of the Cell membrane?

A

Double layer of lipids and proteins that surrounds a cell. It separates the cytoplasm (the contents of the cell) from the external environment.

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18
Q

What is the function of a Mitochondrion?

A

Mitochondria are membrane-bound cell organelles that generate most of the chemical energy needed to power the cell’s biochemical reactions via the release of a Phosphate Ion from ATP to produce ADP.

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19
Q

What is the function of the Endoplasmic Reticulum?

A

A continuous membrane system that forms a series of flattened sacs within the cytoplasm of eukaryotic cells and serves multiple functions, being important particularly in the synthesis, folding, modification, and transport of proteins

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20
Q

What are the four components of DNA used to build the genetic code?

A

Adenine (A) , Guanine (G), Thymine (T), Cytosine (C).

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21
Q

What are the five phases of Mitosis?

A

Interphase - Cell functions normally and Nuclear material is contained within the Nucleus.

Prophase – Each replicated chromosome pairs up with the other. They are joined at the Centromere. Two centrioles separated by mitotic spindle appear at each end of the cell. Nuclear envelope disappears.

Metaphase – Chromatids align down centre of the spindle attached by their centromeres.

Anaphase – The Centromeres separate and Chromosomes drawn to either end of cell as spindles shorten.

Telophase – Mitotic spindle disappears. Nuclear envelope reforms. The plasma membranes and intracellular organelles split. New identical cell formed ready to start G1.

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22
Q

What are the components of blood plasma and what are their functions?

A

Plasma proteins - Albumin stays in circulatory system and regulate osmotic pressure of blood. Stops blood becoming hyper or hypo tonic. Globulins – Fight infection. Clotting factors – Regulate blood clotting and bleeding.

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23
Q

What are the functions of blood?

A

Provision of Oxygen to cells. Removal of Carbon dioxide.

Nutrients from the alimentary tract to the cells. Removal of cell waste products.

Hormones taken to cells to regulate cellular behaviour.

Regulation of heat and temperature.

Transport of protective elements for example white blood cells to fight infection.

Regulates clotting.

24
Q

What is the function of Melanocyte-stimulating hormone (MSH)?

A

Largely unknown but Influences brain activity; excess darkened skin

25
Q
Adrenocorticotropic hormone (ACTH) 
aka corticotropin?
A

Controls production & secretion of cortisol

26
Q

What is the function of Prolactin (PRL)?

A

Helps to promote milk secretion

27
Q

What is the function of Luteinising hormone (LH)

(a gonadotropin)?

A

F: secretion oestrogen & progesterone; ovulation; form corpus luteum.
M: testosterone production

28
Q

What is the function of Follicle-stimulating hormone (FSH) (a gonadotropin)?

A

F: egg development & oestrogen secretion,
M: sperm production

29
Q

What is the function of Human growth hormone (hGH)

aka somatotropin?

A

Promotes growth & repair; regulates metabolism

30
Q

What is the primary function of an Erythrocyte (Red Blood Cell)?

A

To carry oxygen from the lungs to the cells.

31
Q

What is Erythropoeisis, how long does it take, and how long does the resulting organism last?

A

Production of erythrocytes. They have a life span of 120 days. Formation of an Erythrocyte takes 7 days.

32
Q

What is Haemoglobin?

A

Erythrocytes contain haemoglobin, which is a molecule of one part protein to one part Iron, that enables oxygen to be carried. (Oxygen Saturation). Haemoglobin releases oxygen to the plasma to be used by the body.

33
Q

What are the three types of Granulocytes?

A

Neutrophils, Eosinophils, Basophils

34
Q

What are Neutrophils?

A

Neutrophils – small and fast. Scavengers. They kill bacteria by phagocytosis. Drawn to sites of infection in large numbers.

35
Q

What are Eosinophils?

A

Eosinophils – Elimination of parasites such as worms. Kill by chemical toxin release. Associated with allergic reactions and inflammation.

36
Q

What are Basophils?

A

Basophils – Closely associated with allergic reactions. Release heparin and histamine that promote blood vessel permeability and inflammation.

37
Q

What are the three types of Agranulocytes?

A

Monocytes, Macrophages, Lymphocytes

38
Q

What are Monocytes?

A

Monocytes – Associated with fighting infection. Stimulate the production of T lymphocytes. Some Monocytes become Macrophages.

39
Q

What are Macrophages?

A

Macrophages – Kill by phagocytosis. Longer living and more powerful than neutrophils. Produce chemicals called cytokines promote a wider immune system response.

40
Q

What are Lymphocytes?

A

Lymphocytes – Operate in the lymphatic system. Fight cells invaded by cancer, pollen, fungi, bacteria.

41
Q

What are Thrombocytes?

A

Platelets are called thrombocytes.

Promote blood clotting. This is called haemostasis.

They therefore help to prevent haemorrhage or uncontrolled bleeding.

Lifespan of platelets is 8 – 11 days. Those not used are destroyed by macrophages.

42
Q

What are the four ways molecules can be transported in and out of a cell?

A

Simple Diffusion, Channel Mediated, Carrier Mediated, Concentration Gradient

43
Q

Define Cardiac Output.

A

Total amount of blood ejected by Left Ventricle in one minute.

44
Q

Define Stroke Volume.

A

Amount of blood ejected by Left Ventricle in one contraction.

45
Q

Define Heart Rate.

A

Number of contractions of Left Ventricle in one minute.

46
Q

Define Systemic Vascular Resistance.

A

Resistance in vessels. Can be altered by hormones and nervous system as vessels contact and relax.

47
Q

How is Blood Pressure calculated?

A

Cardiac Output (CO) x Systemic Vascular Resistance (SVR) OR Stroke Volume (SV) x Heart Rate (HR) x Systemic Vascular Resistance (SVR)

48
Q

How is Cardiac Output calculated?

A

Stroke Volume (SV) x Heart Rate (HR)

49
Q

Describe the four main types of cancer?

A

Carcinoma – Uncontrolled cell growth. Skin and lining of organs. Basal cell carcinoma, Squamous cell carcinoma, Renal cell carcinoma, Small Cell Carcinoma, Adenocarcinoma.

Myeloma - The malignant proliferation of plasma cells in bone marrow.

Sarcoma – Associated with tumour of the bone.

Leukemia - The malignant proliferation and transformation of white blood cells in the blood.

50
Q

Describe the three stages of shock?

A

Compensated – Increase pulse rate, increase respirations, weak pulse, cool clammy skin, anxiety, thirsty.

Decompensated / Progressive – BP starts to fall, weak slow or no pulse, respiratory rate starts to fall. Altered mental state.

Irreversible or refractory – Severe fall in BP, reduced respiratory effort and rate, no pulse. Loss of consciousness. Cellular hypoxia. Organ death.

51
Q

Describe the 6 types of shock?

A

Hypovolaemic - Active loss of blood from the circulatory system (Haemorrhage) Internal or external. Or lack of blood volume (dehydration). Pump is working but there is reduced blood volume. Also lack of haemoglobin in the case of active bleeding.

Septic - Infection invades a tissue space that is normally sterile. Infection enters the blood stream and goes systemic. Leads to organ failure and death. Bacteria uses oxygen. The body activates the immune complement system. This uses a large amount of oxygen. When bacteria fight cells and immune cells attack bacteria. mediating factors are released ie histamine. Toxins are also released. Cause vasodilation of system and also cause vessels to leak into tissue outside. Causes loss of blood pressure and shock

Neurogenic - Damage to areas of the brain that control tone of vessels in cardiovascular system. Loss of tone in cardiovascular system. Therefore there is a loss of control over Systemic Vascular Resistance. Loss of blood pressure. Loss of cellular oxygen.

Cardiogenic - Failure of the “pump”. Decrease in blood pressure and therefore lack of oxygen to the cells. Many associated causes (Sudden Cardiac Arrest) for example.

Anaphylactic - Immune system of the body recognises something harmless (pollen ) as a threat. Systemic immune response to allergen by white blood cells. Inflammatory cascade. Release of mediating factors i.e. histamine. Cause leakage of blood plasma from circulation to areas outside cardiovascular system. Loss of blood volume. Fall in BP

Traumatic - Vasodilation of cardiovascular system due to sudden emotional fright or trauma. Loss of blood pressure. Loss of cellular oxygen.

52
Q

What is Glomerular Filtration Rate (GFR)?

A

Fluid passing through the glomerulus is called filtrate.

The volume of filtrate created by both kidneys in one minute is called the Glomerular Filtration Rate.

The GFR is 125 ml / min or 180 litres in a day.

Only 1% of filtrate is excreted as urine. This is about 1.5 litres a day.

The rest is reabsorbed by the kidney.

53
Q

What is an Endocrine function?

A

Cells release very specific chemical messenger substances which are carried by the bloodstream to other areas of the body where they are accepted by specific target cells

54
Q

What is an Autocrine function?

A

Cells release chemical messenger substances which are recognised by adjacent cells. By this method a chemical response spreads across an entire tissue of the same cell type

55
Q

What is a Paracrine function?

A

Cells release chemical messenger substances into the fluids around them, where they are picked up by nearby target cells