Physio Day 1 Flashcards
Vit K produced by colonic bacteria
EAS unusual for striated muscle
under ___/___ control
absorbed in colon- specific transporter in ileum
Slight tonic activity
voluntary/reflex
seated position
Sensory receptors
Defecatio reflex
voluntary action inhibits
dec angle, dec resistnace to flow
anal canal, sense gas vs solid
MM causes filling of rectum- sensed by mechanoreceptors, leading to relaxation of IAS/cont EAS
excitation of EAS, resulting in relaxation
Valsalva maneuver
Expire against closed glottis inc ab/thorax pressure
inc defecation, dec VR
HD
Megacoloon
lack of ENS, leading to pain/obs
lose inhib interneurons in MO
constricted colon,
feces accumulates here(Rectosigmoidal jxn)
Other cause of anal incont
weakened EAS/IAS
Blood supply to intestine
few disacch/monosacch
amylose
amylopectin
central lacteal arteriole/venule
ingested
Amylose- straight chain
Amylopectin- branched
BB disacch found on
digested by
Lactase location
Sucrase
Maltase
Cellulase
Apical membrane of microvili in D/J/I
luminal proteases in interdigestie phase
D/J
D/J
maltose to glucose, late Intest
degrade cellulose
Highest absorptive capacity
process
SGLT1 vs SGLT2
D/J
absorb sugar, secrete water to aintain isotonicity
Apical (na dependent)
Basolateral (Na independent)
Scondary AT with SGLT1 on apical membrane
Facilitated diffusion
GLUT5
2 Na for every glucose
GLUT2 on BM
FD- mossttly fructose, some glucose
Dysfunctions due to
severe panc dz
lost disacch
dec SA
geetics
Red digestion leads to poor absorption
Vegetable proteins
Ecto/exo peptidases
pepsin inactive at
inc CHO in colon
incomplete
cleave terminal bonds
pH >4.5
Protein uptake
mult transporters on apical/BM membrane include transporters for
BB transpoters specific to epithelial cells in renal tubules/gut- diffusion on BM
neutral/acidic/basic AA
Cystinuria (SLC7A9 or 3A1)
Dicarboxlic aciduria (SLC1A1)
impaired Neutral/cationic/cysteine uptake
impaired anion uptake
Bacteria in GI system
important substance producer
NO may regulate motility
many diseases
