Pharm extra Flashcards
Prednisone
5ASA (Mesalamine)
Azathioprine
Methotrexate
Class/target
CS- bind GC receptors
Anti-inflam, mult
anti metabolite, IMP/purine syn
Anti metabolite, DHFR, dttP syn
Infliximab
Ustekinumab
Vedolizumab
Hyoscamine
Amitriptyline
Ab- TNF sig
AB, IL12/23 p40
ab a4b7 integrin/leukocyte adhesion
tropane alkaloid, musc receptor antag
anti depr, NE/5HT
SE of 5 aminosalicylic acid
Typical process for 6MP
SE Of 6MP
TPMT
HA, N, diarrhea
start on steroids, wean to 6MP
Rash, N, teratogenic
blocks avtive nucleotide, not very active
dose adjusted 15 fold
Methotrexate pop
works on\
activated by
can be toxic to
severe UC
inhibits DHFR, blocking thymidilate synthesis
glutamates covalently
GI tract/liver
Fusion protein suffix
Monoclonal ab suffix
chimeric
fully humanized
cept
mab
imab/ximab
umab/zumab
IL12/23 share a
Ustekinumab useful for
a4b7 on leukocytes bind
ab for short term chrons
SE of hyoscamine
p40
TNF refractory CD
endothelial VCAM/MADCAM1 for adherence
effective
blurred vision, drowsy
Amytriptaline
serious risk for
Tricyclic AD- inhibits NE and serotonin uptake
overdosage
