PHYSIO Flashcards
Homeostasis refers to dynamic constancy of the body’s internal or ____ compartment fluid
A. Intracellular
B. Extracellular
C. Interstitial
D. Transcellular
B. Extracellular
The greatest contributor to the generation of the resting membrane potential (RMP) is:
A. K+ influx
B. K+ efflux
C. Na+ efflux
D. Na+ influx
B. K+ efflux
When the plasma membrane is at its resting potential
A. Membrane is inexcitable
B. Membrane is more permeable to Na+ than to K+
C. membrane is negative outside relative to the inside
D. there is no net movement of Na+ and K+
D
True of endocytosis but not exocytosis
A. An active process
B. Forms transport vesicle
C. Removes a portion of plasma membrane
D. Moves across but not through membrane
C. Removes a portion of plasma membrane
Which of the following characteristics describe both simple diffusion and facilitated transport?
A. An active transport
B. Requires carrier protein
C. Exhibits saturation
D. Net flux from higher to lower concentration
D. Net flux from higher to lower concentration
Event in bone resorption that happens in ruffled border
A. Extrusion of bicarbonate
B. Acid secretion by H pumps
C. Integrin attachment by vitronectin
D. Clathrin-mediated endocytosis of lysosomal enzymes
B. Acid secretion by H pumps
The osteoclasts possess receptors for
A. Calcitonin only
B. Calcitonin and RANKL only
C. Calcitonin and calcitriol only
D. Calcitonin, RANKL and calcitriol
B. Calcitonin and RANKL only
Hypercalcemia can inhibit parathyroid secretion from the parathyroid gland by:
A. activating the calcium sensor
B. activating the adenylyl cyclase pathway
C. inhibiting protein kinase C
D. inhibiting the phospholipase C pathway
A. activating the calcium sensor
Antigen specificity of immunoglobulin is determined by:
A. Variable heavy & light chains
B. Constant light & variable heavy chains
C. Constant heavy & variable light chains
D. Constant heavy & light chains
A. Variable heavy & light chains
Complement activation requires
A. Plasma protein
B. Previous exposure to antigen
C. Opsonization by bacteria
D. Ag/ab complex
D. Ag/ab complex
Tissue bound macrophages
A. Are stimulated by lymphokines
B. Not found in the lung and liver
C. Digest bacteria using lymphokines
D. Derived from megakaryocytes
A. Are stimulated by lymphokines
Prevents further differentiation of immature cells is clonal
A. deletion
B. abortion
C. ignorance
D. anergy
B. abortion
Division of immune responses into innate and adaptive components are determined by the following, except
A. Development of memory
B. Location in the body
C. Specificity of recognition
D. Kinetics of onset
B. Location in the body
Which of the following is related to pattern-recognition molecules?
A. Can distinguish self from non-self
B. Can tell the difference between discrete genetic variants of a pathogen
C. Fist appear in evolution of mammals
D. Are generated by complex recombination of multiple gene segments
A. Can distinguish self from non-self (Answer in Quiz 2)
B. Can tell the difference between discrete genetic variants of a pathogen (Answer in the bimonthly exam)
NK cells recognize and kill:
A. Normal host cells
B. Cells with increased expression of MHC-I
C. Intracellular pathogens
D. Cells with increased expression of MHC-II
B. Cells with increased expression of MHC-I
Which of the following is false?
A. Memory B cells have high affinity for antigen
B. Long lived plasma cells are mostly found in the spleen
C. Memory B cells constitutively secrete immunoglobulins
D. Generation of long-lived memory B cells need CD4+ T Helper cells
C. Memory B cells constitutively secrete immunoglobulins
Which of the following is false about immune response control
A. Elimination of antigen
B. Apoptosis of previously activated cells
C. Exclusion of cells from the inflammation site
D. Inhibitory receptors
C. Exclusion of cells from the inflammation site
Cytokines primarily involved in T-cell proliferation and development
A. IL-12
B. IL-2 and 7
C. IL-4 and 5
D. TGF - Beta
B. IL-2 and 7
CD4+ T Cell is generally restricted by:
A. CD 22
B. MHC Class I
C. MHC Class II
D. B2 microglobulin
C. MHC Class II
Which of the following are the antigen-specific receptor on mature B cells?
A. IgA
B. IgM
C. IgG
D. IgD
D. IgD
One of the following is true about the bone marrow
A. Very little antibody production
B. Long-term antibody production
C. Antibody production by pre-B cells
D. Substantial secretion of IgD
C. Antibody production by pre-B cells
When a resting naïve T-cell enlarges, what happens to the specific MCH/peptide complex in the absence of co-stimulator?
A. Produces IL-1
B. Undergoes blast cell formation
C. Becomes anergic
D. Moves from G0 to C1 of the cell cycle
C. Becomes anergic
Increase in vertical dimension of chest cage
A. Contraction of diaphragm
B. Contraction of abdominal recti
C. Contraction of internal intercostal
D. Contraction of external intercostal
A. Contraction of diaphragm
The pressure exerted by the alveolar fluid that tends to collapse the lung:
A. Pleural pressure
B. Surface tension
C. Transmural pressure
D. Elastic recoil pressure
B. Surface tension
Based on the Law of Laplace, which of the following is TRUE?
A. Without surfactant, the flow of air tends to go to the bigger alveolus.
B. Without surfactant, there is no pressure gradient between alveoli.
C. With surfactant, the pressure generated is greater in the bigger alveolus.
D. With surfactant, the alveolar pressure is greater in the smaller alveolus.
A. Without surfactant, the flow of air tends to go to the bigger alveolus.
Which of the following reflect/s vital capacity?
A. Inspiratory reserve volume plus expiratory reserve volume
B. Tidal volume plus functional residual capacity
C. Tidal volume plus inspiratory reserve volume plus expiratory reserve volume
D. Functional residual capacity plus inspiratory capacity
C
What is the volume of alveolar air that is renewed by the atmospheric air with each inspiration is
A. 150 ml
B. 250 ml
C. 350 ml
D. 500 ml
C. 350 ml
If the partial pressure of a particular gas in chamber A is 35mm Hg and in Chamber B 85mm Hg, which of the following is true?
A. The gas diffuses from Chamber A to Chamber B
B. There is no movement of molecules across the chambers
C. There is no movement of molecules from Chamber A to Chamber B
D. There is a net partial pressure of 50 mmHg causing the molecules to diffuse to Chamber A
D. There is a net partial pressure of 50 mmHg causing the molecules to diffuse to Chamber A
Which of the following is true regarding factors that determine the partial pressure of gas?
A. The concentration of gas is inversely related to its partial pressure
B. The greater the solubility of the gas in fluid, the greater the partial pressure
C. Humidification of the air does not affect the oxygen partial pressure in the alveoli
D. Gas molecules that are affected to water molecules need a lower partial pressure for diffusion
D. Gas molecules that are affected to water molecules need a lower partial pressure for diffusion
Which of the following increases O2 and hemoglobin dissociation?
A. A pregnant woman
B. A child with hypothermia
C. A patient with metabolic alkalosis
D. A patient with severe dehydration with a serum pH of 4.8
D. A patient with severe dehydration with a serum pH of 4.8
In emphysema, which of these factors affect the rate of diffusion of gas in the respiratory membrane?
A. Diminished surface area
B. Increased membrane thickness due to fibrosis
C. Increased diffusion coefficient
D. Increased pressure difference
A. Diminished surface area
Which of the following shows the correct relationship?
A. Increased blood flow – increased interstitial fluid pO2
B. Increased metabolism – decreased interstitial fluid pCO2
C. Increased blood flow – increased interstitial fluid pCO2
D. Increased metabolism – decreased interstitial fluid pO2
A. Increased blood flow – increased interstitial fluid pO2
D. Increased metabolism – decreased interstitial fluid pO2 (chatgpt)
Which statement is true?
A. The increase in blood flow during exercise decreases the physiologic dead space in the upper part of the lung
B. In the upper portion of the lung, blood low and ventilation is maximal
C. In physiologic shunting, alveolar air becomes equal to the humidified air
D. In the bottom of the lung there is a certain degree of physiologic dead space
A. The increase in blood flow during exercise decreases the physiologic dead space in the upper part of the lung
The average alveolar PO2 is 104 mmHg and the venous blood PO2 is 40 mmHg. The initial pressure difference that caused the O2 to diffuse to the pulmonary capillary is:
A. 23
B. 35
C. 56
D. 64
D. 64
Which of the following is true regarding movement of gas molecules?
A. Net diffusion molecules follow a concentration gradient
B. Free molecules move in a line at high velocity until they strike other molecules
C. Except at absolute zero temperature
D. All of the given choices are correct
D. All of the given choices are correct
The following increases the vertical dimensions of the chest cage
A. Contraction of the external intercostals
B. Contraction of the abdominal recti
C. Contraction of the diaphragm
D. Contraction of the internal intercostal
C. Contraction of the diaphragm
Which of the following characteristics is both common in fast response action potential and slow response action potential
A. Exhibits overshoot potential
B. Uptake is due to Na+ influx
C. Plateau is due to Ca+ influx
D. Repolarization is due to K+ efflux
D. Repolarization is due to K+ efflux
What is true of funny current?
A. It is a hyperpolarizing current
B. It conducts Na & C
C. It is activated when the membrane is depolarized about 10 mV
D. It is a voltage-gated channel
C. It is activated when the membrane is depolarized about 10 mV
What is the heart’s major source of ATP after a heavy carbohydrate meal?
A. Free fatty acids
B. Pyruvates
C. Ketones
D. Triglycerides
A. Free fatty acids
Lead I: R= 5 squares, Q= 2 squares, S= 5 squares. AVF: R= 7 squares, Q= 1 square, no S
MEA is at:
A. 0 degrees
B. 45 degrees
C. 30 degrees
D. 90 degrees
A. 0 degrees
Cardiac systole is the period from closure of AV valve to:
A. Opening of semilunar valves
B. Closure of semilunar valves
C. Opening of AV valves
D. Next closure of AV valves
A. Opening of semilunar valves
Ventricular volume is highest at which phase of the cardiac cycle?
A. Atrial contraction
B. Isovolumetric relaxation
C. Isovolumetric contraction
D. Residual volume
A. Atrial contraction
Aortic pressure is at its lowest at the end of this phase of the cardiac cycle:
A. Atrial contraction
B. Isovolumetric relaxation
C. Isovolumetric contraction
D. Reduced filling
C. Isovolumetric contraction
A change in the following will exert the greatest effect in blood flow
A. Blood viscosity
B. Vessel length
C. Vessel radius
D. Pressure difference
C. Vessel radius
The cardiac output of the right ventricle to the pulmonary circulation is equivalent to what percentage of the cardiac output of the left ventricle to the systemic circulation?
A. 25%
B. 75%
C. 50%
D. 100%
D. 100%
Which of the describes the relationship between wall tension and transmural pressure?
A. Bernoulli’s principle
B. Law of Laplace
C. Poiseuille Law
D. Continuity principle
B. Law of Laplace
The right lymphatic duct drains these areas of the body
A. Lower left quadrant
B. Upper left quadrant
C. Lower right quadrant
D. Upper right quadrant
D. Upper right quadrant
An increase in which of the following can lead to increase in capillary filtration.
A. Mean arterial pressure
B. Resistance in precapillary arterioles
C. Interstitial hydrostatic pressure
D. Albumin in the blood
A. Mean arterial pressure
Venous return is decreased in increased
A. MAP
B. right atrial pressure
C. Mean systemic filling pressure
D. Diameter of arterioles
B. right atrial pressure
A decrease in which of the following can lead to increased mean arterial pressure (MAP)?
A. Venous return
B. Hematocrit
C. Blood volume
D. Body temperature
D. Body temperature
Which step of the pharyngeal stage of swallowing precedes the rest?
A. Palatopharyngeal folds are pulled medially to approximate each other
B. Larynx is pulled up to increase esophageal size
C. Vocal folds are approximated
D. Soft palate is raised to the posterior nares
D. Soft palate is raised to the posterior nares
Which of the following factors will result to the longest gastric emptying time?
A. Chyme pH 7.8
B. 0.1L contents in stomach
C. Isosmotic fluid
D. Polypeptides in the upper duodenum
D. Polypeptides in the upper duodenum
Which of the following motor activities of the bowel will have the LEAST contribution to the caudal movement of chyme?
A. Gastrocolic reflex
B. Segmentation contractions
C. Peristaltic rush
D. Mass movements
B. Segmentation contractions
At which segment of the colon would you expect chyme to be normally mushy
A. Cecum
B. Ascending
C. Transverse
D. Sigmoid
C. Transverse
Which of the following is true about slow waves in the gastrointestinal tract?
A. A type of action potential
B. Causes muscle to contract
C. Intermittent slow depolarizations of resting membrane potential
D. Frequency is greater in the stomach than in small intestine
C. Intermittent slow depolarizations of resting membrane potential
Splanchnic circulation includes the gut and these organs:
A. Spleen, pancreas, liver, and kidney
B. Spleen, pancreas, and liver
C. Spleen and pancreas
D. Spleen
B
Which describes both Auerbach and Meissner plexuses?
A. Extend from the mouth to anus
B. Increase gut motility
C. Increase intestinal absorption
D. Parasympathetic stimulates their activity
D. Parasympathetic stimulates their activity
Which of the ff is secreted by chief cells of gastric mucosa?
A. Intrinsic factor
B. Somat
C. Pepsinogen
D. HCL
C. Pepsinogen
In the esophagus, what provides lubrication for swallowing?
A. Compound mucus glands at gastroesophageal junction
B. mostly mucus glands
C. serous glands
D. tubular glands
B. mostly mucus glands
What structure is responsible for the secretory functions of the large intestine?
A. Crypts of Lieberkuhn
B. Brunner’s gland
C. Serous gland
D. Oxyntic gland
A. Crypts of Lieberkuhn
Which salivary enzyme is identical to pancreatic amylase and cleaves alpha 1,4-glycosidic bonds of carbohydrates?
A. Lingual lipase
B. Secretin
C. Ptyalin
D. Gastrin
C. Ptyalin
What is the most abundant cation in the bile
A. Potassium
B. Chloride
C. Sodium
D. Bicarbonate
C. Sodium
Most potent stimulus for the release of cholecystokinin
A. Bile
B. Secretin
C. Fats
D. Gastrin
C. Fats
Which of the following is true about pancreatic secretions?
A. Cholecystokinin (CCK) causes release of bicarbonate
B. Gastrin stimulates release of enzymes
C. Secretin causes release of enzymes
D. CCK stimulates release of enzymes while secretin stimulates release of bicarbonate
D. CCK stimulates release of enzymes while secretin stimulates release of bicarbonate
The site of bilirubin conjugation
A. Duodenum
B. Kidney
C. Liver
D. Portal circulation
C. Liver
How much of the glomerular filtrate is reabsorbed by the nephrons?
A. 20%
B. 50%
C. 75%
D. 99%
D. 99%
The loops of Henle of the outer cortical nephrons do not descend to the inner medulla. What is true of these nephrons?
A. Are functionally unimportant in the renal conservation of sodium and water
B. Do not contribute to the medullary osmotic gradient
C. Do not participate in the urine diluting mechanism
D. Not functional in the overall kidney function and are simply unimportant
B. Do not contribute to the medullary osmotic gradient
True regarding the proximal convoluted tubule
A. Sodium is “pumped” in and diffuses out passively
B. Sodium diffuses in passively and is “pumped” out
C. Chloried diffuses in passively and is “pumped” out
D. it has a few mitochondria and requires low oxygen
B. Sodium diffuses in passively and is “pumped” out
Patient presents to the ER feeling weak, thirsty and lightheaded. During examination, the mucous membrane appears dry. He tells you that he had recently been hiking but forgot to bring water. Stimulation of the brain by which of the following hormones is responsible for the patient’s thirst?
A. Angiotensin II
B. Renin
C. Angiotensin I
D. Aldosterone
A
Which of the following is true? Removal of the
A. Lungs would cause the loss of rennin
B. Pituitary would cause the loss of aldosterone
C. Kidney would cause the loss of angiotensinogen
D. Zona glomerulosa would cause the loss of aldosterone
D
Which of the following provides the greatest contribution to buffering?
A. Plasma proteins
B. Plasma bicarbonate
C. Red cell bicarbonate
D. Inorganic phosphate
B
Majority of the bicarbonate ions are reabsorbed in which segment of the renal tubules?
A. Proximal convoluted tubule
B. Thick ascending loop of Henle
C. Distal convoluted tubule
D. Collecting duct
A
A 30-year-old man presents to the clinic for possible infertility. He was 6 years married and has been having unprotected intercourse with his wife. He has azoospermia in semen. Low FSH level is found. Lack of stimulation of which of the following cells is responsible for this condition?
A. Leydig cells
B. Sertoli cells
C. Zona fasciculata
D. Zona glomerulosa
B
A 24-year old man went to check up for fertility advice. The result showed azoospermia and low FSH level. Which of the following is most likely the cause of his condition?
A. Apoptosis on spermatogonia
B. Increased estrogen levels
C. Decreased production of testosterone
D. Decreased production of androgen binding proteins
B
A 24-year old man went to check up for fertility advice. The result showed azoospermia and low FSH level. Which of the following is most likely the cause of his condition?
A. Apoptosis on spermatogonia
B. Increased estrogen levels
C. Decreased production of testosterone
D. Decreased production of androgen binding proteins
B
The presentation of hypogonadism:
A. FSH high, LH high, GnRH high, Testosterone low
B. FSH high , LH high, GnRH high, Testosterone high
C. FSH low, LH low, GnRH low, Testosterone high
D. FSH low, LH low, GnRH low, Testosterone low
D
Which of the following hormones is responsible in converting granulosa cells and theca cells to progesterone-secreting cells?
A. GnRH
B. LH
C. GSH
D. Activin
B