Physical Examinations Flashcards
1) Symptoms + Signs + Manifestations
2) Causes (4)
3) Thyroid Hormone Synthesis
i) T4 vs T3
ii) Iodine transport
iii) Iodide oxidisation
iv) Thyroglobulin synthesis
v) Iodinated thyroglobulin –> T3/T4
vi) T4–> T3
vii) plasma constituents
1)
Symptoms - Fatigue, Cold Intolerance, Weight Gain, Dry skin, Coarse Hair, Hoarse voice,
Signs - Periorbital oedema, slow relaxing reflexes, bradycardia, proximal myopathy, Lateral third eyebdrow (sign of hertoghe)
Manifestations - Pericardial effusion, High Cholesterol, Menstrual abnormalities, Hyponatraemia,
2) Causes -
Primary - autoimmune, iatrogenic, iodine deficiency
Secondary - Pituitary
3) Thyroid Hormone Synthesis
i) T4 - 2 iodine atoms in outer ring (4 in total) + T3 - 1 iodine atom in outer ring (3 in total)
ii) Iodine - Against gradient into follicular cells
iii) Iodine transported by pendrin into exocytic vesicles within which they’re oxidised to tyrosyl residues on thyroglobulin catalyzed by thyroid peroxidase
iv) Thyroglobulin is synthesised by RER in follicular cells
v) The iodinated TG is resorbed from colloid back into follicular cells. Phagosomes engulf them in which TG becomes hydrolysed –> T3 + T4
vi) Deiodination recaction by deiodinases
vii) Mainly protein bound - TBG, transthretin, albumin
Treatment:
i) Medical
ii) Surgical
i)
Symptomatic - beta blockade
Carbimazole - Pregnancy. TPO inhibitor
Propylthiouracil - Relatively safe in first trimester of pregnancy. TPO inhibior + inhibitor of peripheral deiodinasation.
Radioiodide - Orbitopathy/ pregnancy are contraindications
Lugol’s Iodine - Inhibits hormonal secretion + by the Wolf-Chaikoff effect prevents organification of iodine in the gland.
Steroids - prevent peripheral conversion of T4-T3
ii) Surgical
Indications: Orbitopathy, Large goitre, Intolerance/refractory to anti-thyroid treatment + CI to radioiodine, Suspicious nodules
1) Gross Anatomy
2) Relations (Where are the nerves)
3) Vasculature
4) What is divided in thyroid surgery
5) Name strap muscles
6) Embryological origin of thyroid gland
1) Ant.to Trachea (attached to 2nd-4th tracheal rings) and Post.to Strap Muscles
Invested by pretracheal fascia (thickens into ligament of berry and attached to the larynx) + has a true capsule
2 Lateral Lobes + isthmus (central)
2) relations:
Ant. - Strap muscles, SCM, Pretracheal fascia
Post. - Larynx, trachea, oesophagus, Pharynx,
Lat. - Carotid Sheath
RLN - Groove tracheoesophagal groove (Near Inf. Thyr Art)
SLN - Deep to upper thyroid pole (near the sup. thyr. art)
3) Vasculature:
Art. - Sup. Thyroid Art. (From ECA)
Inf. Thyr. Artery. (From ThyrCerv Br of SCA)
(Sometimes Thyr. Ima from the Aort. Arch)
Venous - Sup. + Mid Thyr. Vein –> IJV
Inf. Thyr Vein (LL + Isthmus) –> Brachiocephalic Vein
4) Sup to deep:
Skin, Platysma, Inv. Fascia (longitudinally to preserve Ant. Jug Vein), Strap Muscle (upper half to preserve ansa cervicalis nerve supply) , Pretracheal fascia
5) Sternohyoid, Sternoyhyroid, Omohyoid, Thryohyoid,
6) Foramen Caecum of the tongue
1) Unilateral - Manifestations
2) Unilateral - Treatments
3) Bilateral - Manifestations
4) Bilateral - Treatments
1) Unilateral - Breathy Voice, Aspiration Risk, Not usually risk of airway compromise
2) Unilateral- Injection laryngoplasty (lateral to vocal fold to help medially displace the vocal fold), Medialisation thryoplasty (implant placement) or RLN reinnervation
3) Bilateral - Less ofa voice problem. Dyspnoea ranging through to stridor - significant risk of airway compromise
4) Bilateral. Aim is to provide a safe airway. Tracheotomy, Vocal Fold lateralisation, Vocal Cord/Aryetenoid resection, RLN reinnervation
What organs are palpable in a normal abdomen?
Aorta, Lower pole of R Kidney
Surface marking for the neck of pancreas?
Surface marking for the liver?
Surface marking for the gallbladder?
Surface marking for the spleen?
Pancreas - L1 - Transpyloric Plane
Liver- Superior - T4 (nipple line) From right 5th itnercostal space –> left 5th intercostal space
Inferior - Right 10th Rib
Gallbladder - 9th costal cartilage in midclavicular line. L1 transpyloric plane
Spleen - behind 9th-11th Left ribs
Examination features of compartment syndrome?
Treatment - Describe?
Early:
Pain out of keeping with injury, Leg swelling, Pain on passive ankle stretching
Late:
Pulseless, Paraesthesia, paralysis
Fasciotomy:
(Four compartment)
Consent + explain etc.
Two incisions, debride + divide fascia :
Anterior - 2 cm anterior to fibula
Longitudinal incision from tib. tub –> just sup. to ankle
posterior - just medial to posteromedial tibial border
Longitudinal incision from tib. tub –> 5cm above medial malleolus
Forearm Treatment:
Volar Incision Along ulnar border
Dorsal incision (from lateral humeral epicondyle to mid-wrist)
Abdominal Examination
WIPER
General Inspection - Pain, Look around the bed - fluids/ infusions/ medications
Hands - Duputryen’s, palmar erythema, Any nail signs, Liver Flap, Pulse
Face - Scleral icterus, Frenulum, Tongue (glossitis/macroglossia), Apthous Ulcers, pigmentation
Neck - JVP, L Supraclavicular fossa (Virchow’s Node), Spider Naevi
Abdomen - Scars, Drains, hernias (deep breath in/out, cough, lift head off bed), Distended Veins, Size
Palpation - Soft, Deep, Organomegaly, Aorta
Percuss - Ascites, bladder, Liver
Auscultate - Bowel Sounds, Aortic + Renal Bruits
Legs - Pedal Oedema
Complete - DRE, External Genitalia Exam, Observations, Urinalysis, Urine pregnancy test with consent,
Breast Examination
WIPER
General Inspection - Asymmetry, Scars, Nipple inversion, Dimpling, Skin changes, Lumps, Discharge ( ask patient to self express if they say there is any), Scars
Inspection - Hands on hips, Hands behind head, Lean forwards, Look at back
Palpation - (ask for pain first)
Normal breast first - Hand behind head
Palpate four quadrants
Areolar region
Inframammary fold
Axillary region
Axillary tail (ask patient to rest their hand on yours
Supraclavicular nodes
Palpate thoracic spine
Complete - Full history, neurological exam, respiratory exam, abdominal exam
i) Risk Factors for Breast Cancer
ii) Work up for breast cancer
i) Early Menarche / Late Menopause
Nulliparous
FH
HRT
BRCA1 / BRCA 2
ii) Triple Assessment - +ve
Receptor Status
Bloods - incl LFTs + Bone Profile
CXR +/- CT TAP +/- Bone Scan
Surgical Treatments for Breast Cancer
Wide Local Excision - Small tumours/ large breasts
+ SLNB - Blue Dye + Radionucleotide detection
Mastectomy - Tumours >4 cm, Small breasts, Multifocal tumours, Prophylaxis, Central tumours, areolar/peri-areolar
+/- Axillary Clearance - dependent on nodal status at SLNB
i) Hormone treatments available for breast cancer
ii) Breast screening in UK
i) Tamoxifen - Selective Oestrogen Receptor Modulator
Trastazumab - MAB against HER2
Anastrazole - Aromatase inhibitor
ii) 50 - 70 year olds : Every 3 years mammography
Which grafts can be used for CABG
Intermal Mammary
Great Saphenous Vein
Radial Artery
Prosthetic Grafts
What is the sciatic stretch test
Passive SLR:
- Where the pain is preciptated flex the knee.
- If with knee flexion the pain disappears the likely aetiology of the pain is the sciatic nerve
i) Dermatomes tested in Lower Limb Examination
ii) Which nerve roots are the lower limb reflexes interrogating
i) L1 - Inguinal
L2 - Upper thigh
L3 - Knee
L4 - Medial calf
L5 - Lateral calf
S1 - Sole of foot
ii) knee - l3/4
Ankle - S1/S2
5 Red Flag Symptoms for cauda equina syndrome
Severe Back Pain
Bilateral Sciatica
Sexual Dysfunction
Visceral Dysfunction
Saddle Anaesthesia
How to complete cranil nerve exam
Snellen Chart
Ishihara Plates
Smelling Salts
Fundoscopy
Reflexes - Gag, Corneal and Jaw Jerk
Causes of Loss of SMell
Senile Anosmia
Nasal - Tumours, Polyps
Frontal lobe pathology - Meningioma, Trauma, Viruses, Hydrocephalus
i) Cranial nerve VII Nuclei
ii) Branches of Facial nerve given off within the facial canal
i) Motor Nucleus
Sensory Nucleus ( CNV)
Parasympathetic Nuclei:
Lacrimal (–> Pterygopalatine Ganglion –> Greater petrosal nerve –> Lacrimal glands)
Superior Salivary Nucleus (–> Submandibular Ganglion –> These fibers become chorda tympani –> Submandibular Ganglion)
Sympathetic:
Nucleus of tractus solitaries (Taste)
ii) Within the Facial Canal:
Sensory nerve to external auditory meatus
Nerve to stapedius
Greater petrosal Nerve
Chorda Tympani
What does CNIX Do?
- GS to palate, posterior 1/3 tongue, pharynx, tonsils, middle ear
- SS from the Carotid Body/Sinus (CN X does aortic body) + Taste from posterior 1/3 tongue
- Motor fibers to Stylopharyngeus
- Innervates the parotid gland:
Gives off a tympanic branch which synapses with the otic ganglion. Then fibers run in the auriculotemporal nerve (V3) to the parotid gland
Ear Exam
WIPER
Inspection - Away from a wall so you can walk behind
Palpation - Mastoid bone + pinna
Whisper Test
Rhinne’s - 512 hz
Weber’s - 512 hz
CNVII
Romberg’s - Balance impaired eyes open = cerebellar
Balance impaired eyes closed = proprioceptive loss
Otoscopy
Tonsillar Examination
Complete -
Full Cranial Nerve Exam
Otolaryngoscopy - to see the vocal cords
Cervical Node Examination
Describe Weber’s And Rhinne’s Test
Weber
256 Hz tuning fork in middle of forehead
Localises to affected side if conductive loss
Localises to the unaffected side if sensorineural loss
Rhinne’s Test
256 Hz tuning fork on mastoid bone and then in front of ear.
If bone > air then conductive hearing loss
If air > bone + localises to the other side + Rhinne’s test on other side is normal then sensorineural hearing loss
Causes of conductive hearing loss
External Auditory Canal - Wax, Foreign Body, Otitis Externa, Tumour in ear canal, Perforation of tympanic membrane
Middle Ear - OM, Haemotypanum, Cholesteatoma, Otosclerosis
Do a lump exam
Ss Ts and Cs
Size, Shape, Site
Transillumination, Tednerness, Temperature, Tethering
Colour, Compressibility, Consistency, Contour
Extras:
Cough Impulse
Auscultate
Pulsatility
Lymphadenopathy
Neurovascular status (in all limb lumps)
Completion:
Cardiorespiratory exam to assess for fitness for surgery