phospholipids/fatty acid synthesis

Question 1

Where does fatty acid synthesis take place?

Answer 1

cytosol

Question 2

Name the type of lipids in biochem

Answer 2

fatty acids, triglycerides, phospholipids and sterols

Question 3

What is the final product of fatty acid synthesis?

Answer 3

palmitate

Question 4

What is the starting material in fatty acid synthesis?

Answer 4

acetyl CoA

Question 5

Where does NADPH come from?

Answer 5

pentophosphate pathway

Question 6

What diseases occur due to fatty acids?

Answer 6

• cancer
• diabetes T2
  obesity
  alcoholism

Question 7

Activation occurs via:

Answer 7

carboxylation

Question 8

How is fatty acid released from the complex/

Answer 8

via thiolysis

Question 9

What does the synthesis of a molecule of fatty acid require?

Answer 9

• 7 ATP
• 8 acetyl CoA
• 14 NADPH

Question 10

What is fatty acid synthesis downregulated by?

Answer 10

• palmitate
  -glucagon
  -adrenaline
  -phosphorylation

Question 11

What does the citrate carrier enable?

Answer 11

enables acetyl CoA to be moved from the mitochondrial matrix to the cytosol

Question 12

What are the essential fatty acids?

Answer 12

• linoleic acid
  -linolenic acid

Question 13

What is fatty acid synthesis down regulated by?

Answer 13

diabetes

Question 14

Where are phospholipids synthesised ?

Answer 14

on the endoplasmic reticulum

Question 15

What phospholipid has a role in apoptosis?

Answer 15

phosphatidyl inositol

Question 16

What is ceramide?

Answer 16

an intermidiate in sphingolipid synthesis\

Question 17

What is the regulatory enzyme in fatty acid synthesis?

Answer 17

Acetyl CoA carboxylase

Question 18

What does the citrate carrier enable?

Answer 18

Enables acetyl CoA to be moved from the cytosol to mitochondrial matrix