Phosphodiesterase (PDE) Inhibitor

Question 1

Sildenafil
MOA

Answer 1

Vasodilate smooth muscle copora cavernosa, increases blood flow to the cavenosa resulting in swelling and penile erection. Does this be inhibiting PDE 5. This increases conc of cGMP which inhibits the contraction of muscle allowing relaxation

Question 2

Sildenafil
Abs/Distrb/Elim

Answer 2

Given orally, peak action occurs in 30–120min.

Question 3

Sildenafil
Clinical use

Answer 3

Erectile dysfunction
Pulmonary Hypertension

Question 4

Sildenafil
Adverse effects

Answer 4

Flushing
Headaches
Dyspepsia
Decreased blood pressure