Angiotensin II Receptor Antagonists Flashcards
1
Q
Losartan / Candesartan / Valsartan
MOA
A
Lowers blood pressure by decreasing vasoconstriction. Blocks the action of angiotensin II on the angiotensin II (AT1 subtype) receptor.
2
Q
Losartan / Candesartan / Valsartan
Abs/ Distrb / Elim
A
Orally
Losartan half life 6hrs
Candesartan half life 8hrs
Valsartan half life 10hrs
3
Q
Losartan / Candesartan / Valsartan
Clinical use
A
Hypertension
Heart failure
4
Q
Losartan / Candesartan / Valsartan
Adverse effects
A
Hypotension initial doses
Reversible renal impairment
Hyperkalemia (if taken with potassium-sparing diuretics)
Similar clinical effect as ACE inhibitors without dry cough