Angiotensin II Receptor Antagonists Flashcards

1
Q

Losartan / Candesartan / Valsartan
MOA

A

Lowers blood pressure by decreasing vasoconstriction. Blocks the action of angiotensin II on the angiotensin II (AT1 subtype) receptor.

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2
Q

Losartan / Candesartan / Valsartan
Abs/ Distrb / Elim

A

Orally
Losartan half life 6hrs
Candesartan half life 8hrs
Valsartan half life 10hrs

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3
Q

Losartan / Candesartan / Valsartan
Clinical use

A

Hypertension
Heart failure

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4
Q

Losartan / Candesartan / Valsartan
Adverse effects

A

Hypotension initial doses
Reversible renal impairment
Hyperkalemia (if taken with potassium-sparing diuretics)

Similar clinical effect as ACE inhibitors without dry cough

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