Phosphate homeostasis Flashcards
1
Q
Name 3 things the regulate phosphate?
A
PTH
Vit D
FGF-23
2
Q
How does PTH effect phosphate lvls?
A
Decrease kidney reabsorption
Increase renal excretion
3
Q
What is main regulator of phosphate?
A
FGF-23
4
Q
What produces FGF-23?
A
Osteocytes
Rise phosphate lvls
5
Q
When is FGF-23 produced?
A
Rise in phosphate lvls
6
Q
What is effect of FGF-23?
A
Decrease phosphate
Decrease vit D3 hydroxylation- decrease gut absorp
7
Q
What is needed for FGF-23 to work?
A
Klotho
8
Q
Does PTH secretion increase or decrease serum phosphate? Why?
A
Decrease as PTH increases excretion of phosphate in renal tubules
9
Q
What will increased phosphate lvls trigger?
A
Rise FGF-23 and rise PTH
