Phosphate

Question 1

How much phosphate is present in human body?
Where present?

Answer 1

500-800g
Bone mineral- 85%
Soft tissues- 14%
Serum and ECF- 1%

Question 2

State ways which body uses phosphate?

Answer 2

1) Cell membrane- phospholipid bilayer
- head of phospholipid
2) DNA and nucleic acid- linked by phosphate
3) ATP
4) Intracellular signalling- addition and removal
5) Bone mineral- calcium hydroxyapatite

Question 3

What is mineral in bones?

Answer 3

Calcium hydroxyapatite

Question 4

What does high phosphate levels result in?

Answer 4

Excessive formation hydroxyapatite
Calcifications

Question 5

What does low phosphate result in?

Answer 5

Poor bone mineralisation
Rickets

Question 6

Is phosphate filtered?
IS it reabsorbed?

Answer 6

Unbound phosphate- filtered
80% reabsorbed via proximal tubule
10% reabsorbed via distal tubule

Question 7

How much phosphate is unbound?
How much phosphate bound?

Answer 7

Unbound- 90%
Bound- 10% (protein)

Question 8

How is phosphate reabsorbed renally (2)?

Answer 8

80% reabsorbed via proximal tubule
10% reabsorbed via distal tubule

Question 9

Name 3 sources of phosphate?

Answer 9

Dairy
Soy
Seeds

Question 10

Answer 10