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PHA6124 LAB Manufacturing Pharmacy > Phenoxymethyl Penicillin K Granules > Flashcards

Phenoxymethyl Penicillin K Granules Flashcards

1
Q

prepared agglomerates of smaller particle size

A

Granules

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2
Q

granules are ____________________ but may be prepared to be _________ & behaved as a single particle

A

Irregularly shaped; spherical

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3
Q

granules make use of sieve # _______

A

4-12

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4
Q

one disadvantage of powders as the ingredients may segregate either on the hoppers of packaging machines or in the storage of final bulk containers

A

particle size differences

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5
Q

the product will be non-uniform and the patient will not receive the same dose of the active
ingredient on administration

A

particle size differences

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6
Q

particle size differences can be minimized by ___________________ of the mixture or mixed powders during preparation

A

efficient granulation

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7
Q

preparations consisting of SOLVENT, DRY AGGREGATES of powder particles sufficiently RESISTANT to withstand handling

A

granules

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8
Q

granules mode of admin

A

oral (swallowed, chewed, dissolved or dispersed in water for another suitable solvent)

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9
Q

T/F: granules contain ONE OR MORE substances WITH OR WITHOUT excipients and if possible, suitable FLAVORANT OR COLORANT substances can be added

A

True

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10
Q

granules are mainly used for __________________________

A

low toxicity, hydrous drugs

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11
Q

used for bulk-forming laxative
and have a dose of 1 to 4 grams daily

A

methylcellulose granules

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12
Q

presented as SINGLE dose or MULTIPLE dose preparation

A

granules

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13
Q

T/F: Each dose of a SINGLE DOSE preparation is administered by means of a DEVICE suitable for measuring the quantity prescribed

A

False (multidose)

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14
Q

each dose is enclosed in an INDIVIDUAL container
such as a SACHET or VIAL

A

single dose granules

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15
Q

if the preparation contains ___________ ingredients or the contents have to be protected, they should be stored in _______________________

A

volatile; airtight container

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16
Q

granules categories

A
  1. effervescent granules
  2. coated granules
  3. gastro-resistant granules
  4. modified-release granules
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17
Q

uncoated granules generally containing acid substances and CARBONATES or HYDROGEN CARBONATES

A

effervescent granules

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18
Q

react RAPIDLY in the presence of WATER and RELEASE CO2

A

effervescent granules

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19
Q

The effervescence and subsequent disintegration of the granules should be complete within ______________ at which time the granule ingredients should be either ______________________ in the water

A

5 minutes; dissolved or dispersed

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20
Q

storage of prepped effervescent granules

A

airtight container

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21
Q

consists of granules COATED with one or more layers of mixtures of various EXCIPIENTS

A

coated granules

22
Q

The substances used as coatings, generally__________ are usually applied as _______________________ in conditions in which EVAPORATION of the vehicle LEAVES A FILM OF COATING

A

polymers; solution or suspension

23
Q

enteric coated granules

A

gastro-resistant granules

24
Q

gastro-resistant granules are __________________ intended to resist the gastric fluid to
release the active substances in the intestine fluid

A

delayed release granules

25
Q

gastro-resistant granules are generally achieved by covering the granules with ______________________

A

a gastro-resistant polymer

26
Q

Coated or uncoated granules that contains SPECIAL EXCIPIENTS
prepared by special procedures are both designed to MODIFY the rate, the place or the time at which the active substance/s are released

A

modified-release granules

27
Q

modified-release granules may have __________________ or ______________________ properties

A

prolonged-release or delayed-release

28
Q

Pharmaceutical process which attempts to convert powdered materials into aggregates called granules

A

granulation

29
Q

Ways of Granulations

A
  1. Granulating machine/Granulator
  2. Wet granulation
  3. Fluid Bed Granulation
30
Q

T/F: Granules FLOW BETTER than powders

A

True

31
Q

Granules _______________ compressibility

A

increase

32
Q

Granules have _______________ than a comparable volume of powders

A

smaller surface area

33
Q

smaller surface area makes granules more stable ________________________ than the corresponding powders

A

physically and chemically

34
Q

Granules are __________________ by a solvent than are certain powders, so that granules are also _____________ in making solutions

A

more easily wetted; preferred

35
Q

Granules produce _____________________, thus content uniformity

A

particle-size uniformity

36
Q

Allows granulation with or without moisture

A

Granulating machine/Granulator

37
Q

Employed in large scale manufacturing

A

Granulating machine/Granulator

38
Q

granules are formed by compacting large masses of the powder mixture and subsequently crushing into pieces

A

dry granulation

39
Q

The dry granulation method requires the drug or the diluent to
have ______________________ for the large masses to be formed

A

cohesive properties

40
Q

The powder is ______________ or compressed into large flat tablets or
pellets of about ____________ (3/4 inch or larger) in diameter

A

“slugged”; 1 inch

41
Q

Involves wetting powder mixture, sieving & drying in preparation of
granules

A

wet granulation

42
Q

during wet granulation, a ________________ or an ____________ is first added to the powder mixture

A

liquid binder or an adhesive

43
Q

A granulating solution is sprayed onto the suspended particles that
are then dried rapidly in the suspending air

A

fluid bed granulation

44
Q

Benzyl penicillin

A

Pen G

45
Q

Phenoxymethyl

A

Pen V

46
Q

modified penicillin having C6H5OCH2 as radical

A

Pen V

47
Q

relatively stable in the presence of gastric acidity, soluble in
duodenal fluids and orally effective without buffer

A

Pen V

48
Q

pharmacologic category of Phenoxymethyl Penicillin Potassium (Granules for Oral Suspension)

A

antibacterial

49
Q

Anti-infective derived from natural source

A

antibacterial

50
Q

Provides faster and higher blood level than phenoxymethyl penicillin

A

Oral Pen V. Potassium

51
Q

T/F: Phenoxymethyl Penicillin Potassium must be manufactured in a separate area from non-
penicillin

A

True

52
Q

why must Phenoxymethyl Penicillin Potassium be manufactured in a separate area

A
  1. To prevent contamination
  2. May be hazardous to personnel who are hypersensitive to penicillin

PHA6124 LAB Manufacturing Pharmacy (3 decks)

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