Phenoxymethyl Penicillin K Granules

Question 1

prepared agglomerates of smaller particle size

Answer 1

Granules

Question 2

granules are ____________________ but may be prepared to be _________ & behaved as a single particle

Answer 2

Irregularly shaped; spherical

Question 3

granules make use of sieve # _______

Answer 3

4-12

Question 4

one disadvantage of powders as the ingredients may segregate either on the hoppers of packaging machines or in the storage of final bulk containers

Answer 4

particle size differences

Question 5

the product will be non-uniform and the patient will not receive the same dose of the active
ingredient on administration

Answer 5

particle size differences

Question 6

particle size differences can be minimized by ___________________ of the mixture or mixed powders during preparation

Answer 6

efficient granulation

Question 7

preparations consisting of SOLVENT, DRY AGGREGATES of powder particles sufficiently RESISTANT to withstand handling

Answer 7

granules

Question 8

granules mode of admin

Answer 8

oral (swallowed, chewed, dissolved or dispersed in water for another suitable solvent)

Question 9

T/F: granules contain ONE OR MORE substances WITH OR WITHOUT excipients and if possible, suitable FLAVORANT OR COLORANT substances can be added

Answer 9

True

Question 10

granules are mainly used for __________________________

Answer 10

low toxicity, hydrous drugs

Question 11

used for bulk-forming laxative
and have a dose of 1 to 4 grams daily

Answer 11

methylcellulose granules

Question 12

presented as SINGLE dose or MULTIPLE dose preparation

Answer 12

granules

Question 13

T/F: Each dose of a SINGLE DOSE preparation is administered by means of a DEVICE suitable for measuring the quantity prescribed

Answer 13

False (multidose)

Question 14

each dose is enclosed in an INDIVIDUAL container
such as a SACHET or VIAL

Answer 14

single dose granules

Question 15

if the preparation contains ___________ ingredients or the contents have to be protected, they should be stored in _______________________

Answer 15

volatile; airtight container

Question 16

granules categories

Answer 16

1. effervescent granules
2. coated granules
3. gastro-resistant granules
4. modified-release granules

Question 17

uncoated granules generally containing acid substances and CARBONATES or HYDROGEN CARBONATES

Answer 17

effervescent granules

Question 18

react RAPIDLY in the presence of WATER and RELEASE CO2

Answer 18

effervescent granules

Question 19

The effervescence and subsequent disintegration of the granules should be complete within ______________ at which time the granule ingredients should be either ______________________ in the water

Answer 19

5 minutes; dissolved or dispersed

Question 20

storage of prepped effervescent granules

Answer 20

airtight container

Question 21

consists of granules COATED with one or more layers of mixtures of various EXCIPIENTS

Answer 21

coated granules

Question 22

The substances used as coatings, generally__________ are usually applied as _______________________ in conditions in which EVAPORATION of the vehicle LEAVES A FILM OF COATING

Answer 22

polymers; solution or suspension

Question 23

enteric coated granules

Answer 23

gastro-resistant granules

Question 24

gastro-resistant granules are __________________ intended to resist the gastric fluid to
release the active substances in the intestine fluid

Answer 24

delayed release granules

Question 25

gastro-resistant granules are generally achieved by covering the granules with ______________________

Answer 25

a gastro-resistant polymer

Question 26

Coated or uncoated granules that contains SPECIAL EXCIPIENTS prepared by special procedures are both designed to MODIFY the rate, the place or the time at which the active substance/s are released

Answer 26

modified-release granules

Question 27

modified-release granules may have __________________ or ______________________ properties

Answer 27

prolonged-release or delayed-release

Question 28

Pharmaceutical process which attempts to convert powdered materials into aggregates called granules

Answer 28

granulation

Question 29

Ways of Granulations

Answer 29

1. Granulating machine/Granulator 2. Wet granulation 3. Fluid Bed Granulation

Question 30

T/F: Granules FLOW BETTER than powders

Answer 30

True

Question 31

Granules _______________ compressibility

Answer 31

increase

Question 32

Granules have _______________ than a comparable volume of powders

Answer 32

smaller surface area

Question 33

smaller surface area makes granules more stable ________________________ than the corresponding powders

Answer 33

physically and chemically

Question 34

Granules are __________________ by a solvent than are certain powders, so that granules are also _____________ in making solutions

Answer 34

more easily wetted; preferred

Question 35

Granules produce _____________________, thus content uniformity

Answer 35

particle-size uniformity

Question 36

Allows granulation with or without moisture

Answer 36

Granulating machine/Granulator

Question 37

Employed in large scale manufacturing

Answer 37

Granulating machine/Granulator

Question 38

granules are formed by compacting large masses of the powder mixture and subsequently crushing into pieces

Answer 38

dry granulation

Question 39

The dry granulation method requires the drug or the diluent to have ______________________ for the large masses to be formed

Answer 39

cohesive properties

Question 40

The powder is ______________ or compressed into large flat tablets or pellets of about ____________ (3/4 inch or larger) in diameter

Answer 40

“slugged”; 1 inch

Question 41

Involves wetting powder mixture, sieving & drying in preparation of granules

Answer 41

wet granulation

Question 42

during wet granulation, a ________________ or an ____________ is first added to the powder mixture

Answer 42

liquid binder or an adhesive

Question 43

A granulating solution is sprayed onto the suspended particles that are then dried rapidly in the suspending air

Answer 43

fluid bed granulation

Question 44

Benzyl penicillin

Answer 44

Pen G

Question 45

Phenoxymethyl

Answer 45

Pen V

Question 46

modified penicillin having C6H5OCH2 as radical

Answer 46

Pen V

Question 47

relatively stable in the presence of gastric acidity, soluble in duodenal fluids and orally effective without buffer

Answer 47

Pen V

Question 48

pharmacologic category of Phenoxymethyl Penicillin Potassium (Granules for Oral Suspension)

Answer 48

antibacterial

Question 49

Anti-infective derived from natural source

Answer 49

antibacterial

Question 50

Provides faster and higher blood level than phenoxymethyl penicillin

Answer 50

Oral Pen V. Potassium

Question 51

T/F: Phenoxymethyl Penicillin Potassium must be manufactured in a separate area from non- penicillin

Answer 51

True

Question 52

why must Phenoxymethyl Penicillin Potassium be manufactured in a separate area

Answer 52

1. To prevent contamination 2. May be hazardous to personnel who are hypersensitive to penicillin