AlMgOH Oral Suspension Flashcards
disperse system in which INTERNAL phase is dispersed UNIFORMLY as FINELY DIVIDED INSOLUBLE particles throughout the external phase
suspension
consist of INSOLUBLE SOLID PARTICLES having the range from 0.5-5 microns which is maintained uniformly throughout the suspending vehicle
internal phase
generally AQUEOUS and in some instances, it may be an ORGANIC liquid or OILY liquid for non-oral use
external phase
suspension classification based on GENERAL CLASSES
- oral susp
- externally applied suspension
- parenteral susp
suspension classification based on PROPORTION OF SOLID PARTICLES
- diluted susp
- concentrated susp
suspension classification based on ELECTRO KINETIC NATURE of solid particles
- flocculated susp
- deflocculated susp
suspension classification based on SIZE OF SOLID PARTICLES
- colloidal susp
- coarse susp
what type of suspension?
2-10% w/v solid
diluted susp
what type of suspension?
50% w/v soli
concentrated susp
what type of suspension?
1-500 nm in diameter
colloidal susp
what type of suspension?
more than 500 nm in diameter
coarse susp
reasons for susp formulation
- sustaining effect
- stability
- taste
- basic solubility
When drug is ________________ in the ______________________, we opt to manufacture or produce pharmaceutical suspension
insoluble in the delivery vehicle
components of a suspension
- API
- wetting agent
- flocculating agents
- viscosity agents
- buffer
- preservative, colorant, flavorant
- water, glycerin, sorbitol
pharmacologic category of Aluminum Magnesium Hydroxide Suspension
antacid
Antacids _______________ gastric acidity resulting in an ____________ in the pH of the ______________ and in the ______________
reduce gastric acidity; increase pH of stomach and duodenum
neutralize excess gastric hydrochloric acid associated with gastritis and peptic ulcer
antacid
Most antacids raise the gastric pH to ____________
4-5
uses of antacid
for:
1. uncomfortable feeling from overeating
2. heartburn
3. dyspepsia (indigestion)
4. duodenal ulcer
5. other non-specific GI symptoms
Al(OH)3 and MgOH2 are ____________________ in nature
basic (weak bases)
Ideal antacid and soluble in acidic medium
Al(OH)3
Al(OH)3 color
white
Al(OH)3 is a viscous suspension or _____________
a gel
pH range of Al(OH)3
pH 5.5 – 8.0
Al(OH)3 may ____________ with the absorption of other drugs by __________ with them (e.g. tetracycline)
interfere; binding
Al(OH)3 can cause __________________
constipation
constipation is due to production of ___________, a water soluble
astringent salt from Al(OH)3 and HCl
AlCl3
characteristics of MgOH2
white, fine odorless, amorphous powder
MgOH2 is ____________ in water and alcohol but _____________ in dilute acids
insoluble; soluble
used as laxatives in high doses
MgOH2
Advantages of MgOH2
- fast onset of action
- no systemic alkalosis
- high acid neutralizing capacity
Disadvantages of MgOH2
- short doa
- laxative/diarrhea
- hypermagnesia
- CI to px with kidney disease
mL of water added upon addition of MgOH2 and sorbitol
100 mL
minutes of agitation before addition of Al(OH)3
5 minutes
CMC is placed in _________ after which 50 mL water is added
mortar
mL of water heated to 50 degrees before adding dissolved saccharin sodium and sodium benzoate
50 mL
role of sorbitol
wetting agent
role of carboxymethyl cellulose
suspending agentr
role of peppermint oil
flavorant
role of saccharin sodium
sweetening agent
role of sodium benzoate
preservative
role of purified water
solvent
Examples of flocculating agents
Calcium chloride, aluminum chloride
Examples of wetting agents
Sodium lauryl sulfate, benzalkonium chloride
Examples of viscosity agents or suspending agents/thickeners
Methyl cellulose, bentonite, tragacanth
Wetting agents are also known as
Surfactants
Added to DISPERSE SOLID PARTICLES in the EXTERNAL PHASE
Wetting agents or surfactants
Stabilize the suspension to a desired pH range
Buffer
