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PHA6124 LAB Manufacturing Pharmacy > AlMgOH Oral Suspension > Flashcards

AlMgOH Oral Suspension Flashcards

1
Q

disperse system in which INTERNAL phase is dispersed UNIFORMLY as FINELY DIVIDED INSOLUBLE particles throughout the external phase

A

suspension

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2
Q

consist of INSOLUBLE SOLID PARTICLES having the range from 0.5-5 microns which is maintained uniformly throughout the suspending vehicle

A

internal phase

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3
Q

generally AQUEOUS and in some instances, it may be an ORGANIC liquid or OILY liquid for non-oral use

A

external phase

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4
Q

suspension classification based on GENERAL CLASSES

A
  1. oral susp
  2. externally applied suspension
  3. parenteral susp
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5
Q

suspension classification based on PROPORTION OF SOLID PARTICLES

A
  1. diluted susp
  2. concentrated susp
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6
Q

suspension classification based on ELECTRO KINETIC NATURE of solid particles

A
  1. flocculated susp
  2. deflocculated susp
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7
Q

suspension classification based on SIZE OF SOLID PARTICLES

A
  1. colloidal susp
  2. coarse susp
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8
Q

what type of suspension?
2-10% w/v solid

A

diluted susp

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9
Q

what type of suspension?
50% w/v soli

A

concentrated susp

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10
Q

what type of suspension?
1-500 nm in diameter

A

colloidal susp

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11
Q

what type of suspension?
more than 500 nm in diameter

A

coarse susp

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12
Q

reasons for susp formulation

A
  1. sustaining effect
  2. stability
  3. taste
  4. basic solubility
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13
Q

When drug is ________________ in the ______________________, we opt to manufacture or produce pharmaceutical suspension

A

insoluble in the delivery vehicle

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14
Q

components of a suspension

A
  1. API
  2. wetting agent
  3. flocculating agents
  4. viscosity agents
  5. buffer
  6. preservative, colorant, flavorant
  7. water, glycerin, sorbitol
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15
Q

pharmacologic category of Aluminum Magnesium Hydroxide Suspension

A

antacid

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16
Q

Antacids _______________ gastric acidity resulting in an ____________ in the pH of the ______________ and in the ______________

A

reduce gastric acidity; increase pH of stomach and duodenum

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17
Q

neutralize excess gastric hydrochloric acid associated with gastritis and peptic ulcer

A

antacid

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18
Q

Most antacids raise the gastric pH to ____________

A

4-5

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19
Q

uses of antacid

A

for:
1. uncomfortable feeling from overeating
2. heartburn
3. dyspepsia (indigestion)
4. duodenal ulcer
5. other non-specific GI symptoms

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20
Q

Al(OH)3 and MgOH2 are ____________________ in nature

A

basic (weak bases)

21
Q

Ideal antacid and soluble in acidic medium

A

Al(OH)3

22
Q

Al(OH)3 color

A

white

23
Q

Al(OH)3 is a viscous suspension or _____________

A

a gel

24
Q

pH range of Al(OH)3

A

pH 5.5 – 8.0

25
Q

Al(OH)3 may ____________ with the absorption of other drugs by __________ with them (e.g. tetracycline)

A

interfere; binding

26
Q

Al(OH)3 can cause __________________

A

constipation

27
Q

constipation is due to production of ___________, a water soluble
astringent salt from Al(OH)3 and HCl

A

AlCl3

28
Q

characteristics of MgOH2

A

white, fine odorless, amorphous powder

29
Q

MgOH2 is ____________ in water and alcohol but _____________ in dilute acids

A

insoluble; soluble

30
Q

used as laxatives in high doses

A

MgOH2

31
Q

Advantages of MgOH2

A
  1. fast onset of action
  2. no systemic alkalosis
  3. high acid neutralizing capacity
32
Q

Disadvantages of MgOH2

A
  1. short doa
  2. laxative/diarrhea
  3. hypermagnesia
  4. CI to px with kidney disease
33
Q

mL of water added upon addition of MgOH2 and sorbitol

A

100 mL

34
Q

minutes of agitation before addition of Al(OH)3

A

5 minutes

35
Q

CMC is placed in _________ after which 50 mL water is added

A

mortar

36
Q

mL of water heated to 50 degrees before adding dissolved saccharin sodium and sodium benzoate

A

50 mL

37
Q

role of sorbitol

A

wetting agent

38
Q

role of carboxymethyl cellulose

A

suspending agentr

39
Q

role of peppermint oil

A

flavorant

40
Q

role of saccharin sodium

A

sweetening agent

41
Q

role of sodium benzoate

A

preservative

42
Q

role of purified water

A

solvent

43
Q

Examples of flocculating agents

A

Calcium chloride, aluminum chloride

44
Q

Examples of wetting agents

A

Sodium lauryl sulfate, benzalkonium chloride

45
Q

Examples of viscosity agents or suspending agents/thickeners

A

Methyl cellulose, bentonite, tragacanth

46
Q

Wetting agents are also known as

A

Surfactants

47
Q

Added to DISPERSE SOLID PARTICLES in the EXTERNAL PHASE

A

Wetting agents or surfactants

48
Q

Stabilize the suspension to a desired pH range

A

Buffer

PHA6124 LAB Manufacturing Pharmacy (3 decks)

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