Phenothiazines

Question 1

What drugs are in the phenothiazine class?

Answer 1

Acepromazine (ACE)

Question 2

What is ace used for?

Answer 2

Premed, sedative (Good sedation)

Need opioid for better pain control
True tranquilizer

Antiemetic
Antihistamine
Anti-arrhythmic
Mild sedative

Question 3

Does ACE provide analgesic properties?

Answer 3

No

Question 4

Is ACE a controlled drug?

Answer 4

No

Question 5

ACE’s Mode of action

Answer 5

Targets alpha 1 agonist adrenergic receptors

Dopamine antagonist - antiemetic (mu opioids)

Antihistamine- (morphine) perception pathway 🧠

Question 6

Negatives of phenothiazines

Answer 6

No analgesia
Not reversible
Decreases seizure threshold
Hard on the heart ❤️ Vasodilation- hypotension (dose dependant)
Hypothermia
Prolapse of penis

Breed differences- boxer exaggerated rxns

CAUTION in patients w renal, hepatic and heart valve dz (hemorrhage +/- bleeding disorders)

Question 7

Benefits of phenothiazines (ACE)

Answer 7

Antiemetic
Antihistamine
Anti-arrhythmic
Mild sedation
Tranquilizer
Decreases anesthesic gas needed

Question 8

ACE: onset & duration

Answer 8

Onset: 15 min IM or IV
Duration: 4-12 hrs