Phase I and II

Question 1

What are the Phase I reactions, enzymes involved, and cofactors?

Answer 1

Aromatic and alipathic hydroxylation; addition of an OH to a free carbon; cytochrome P450 monooxygenase;

Question 2

Phase II reactions, enzymes, and cofactors

Answer 2

Acetylation; N-acetyltransferase; cofactor: A-CoA (attach to amine group); Sulfation–sulfotransferase, PAPS; glucuronidation–UDP-glucuronosyltransferase, cofactor: UDP-glucuronic acid