ADME Flashcards
Disposition factors
- Rate of absorption
- Metabolism
- Concentration in tissues other than the target ones
- Rapidity of elimination
- storage
Most important excretory pathway
Renal
4 main factors that affect distribution
lipophilicity, blood flow to organs (perfusion), barriers, plasma protein binding and tissue protein binding
What is the difference bw metallothionein in liver and kidney?
in kidney–binds zn and cdin P.C.T; in liver, binds Pb–>stored as Ca is stored bc bone can’t distinguish bw either
What is dieldrin?
An organochlorine that is v lipid soluble–> 99% bound to albumin–>sticks around in body for a long time–>competes for “seats on the bus”
Storage sites for xenos
plasma proteins, tissues (fat), bone, cellular binding sites
most important site for transformation?
liver
most important determinant in a xeno’s duration in the body?
biotransformation
3 processes in changing the blood level of a xeno
Glomerular filtration; tubular reabsorption; tubular secretion
pH of the kidney filtrate
6.8
what kind of molecules is biliary excretion used for?
molecules larger than 350g/mol
what is bioaccumulation?
the total accumulation of xenos from all sources (food, air, water, etc)
what is bioconcentration?
accumulation in aq exposures
what is BCF?
bioconcentration factor, conc of xeno in clam/water etc
what is biomagnification?
food chain transfer–> fish eats lots of plankton, accumulation in fish–>we eat lots of fish, now we have tons of xeno in us
