Pharmokinetics and Pharmodynamics

Question 1

Define Pharmokinetics

Answer 1

What the BODY does to the drugs

Question 2

Define Pharmodynamics

Answer 2

What the Drug does to the body

dYNAMICS dRUG

Question 3

Define bioavailability

Answer 3

Proportion of administered drug which reaches the systemic circulation

Question 4

What can affect bioavailability?

Answer 4

Dependent on extent of drug absorption and extent of first pass metabolism
Not affected by rate of absorption
Varies with route of administration
Variation between individuals (genetic, disease states)
Expressed as % or fraction (e.g 70% or 0.7)