Pharmocology Flashcards
spironalactone se
hyperkalaemia
- peak t, small p, wide qrs
ccb for htn
nifed, amlod
se - ankle swelling, dizzyness
methotrexate se
can get pneumonitis
myelofibrosis
liver fibrosis
renal
animal bite abx
co-amoxiclav
drugs in ALS
1 mg adrenaline 3-5mins
amiodarone after 3rd shock
not atropine
clindamycin prob
commonly linked to c diff
treat c diff
metronidazole
cocaine affects
heart
neuropsych
hypertension
rhabdo
met acid
statin
myopathy
liver probs
- monitor LFT’s before and during
- stop if reach 3 times normal
take at night
amlodipine main se
ankle swell
thiazide main se
hyponat
others
- postural hypotension, dehydration
- hypokal, hypercal
- gout
- impaired gluc tol
b-block main side
cold periph
what to avoid in renal failure
tetracycline
nsaid
metformin
lithium
safe in renal failure
rifampicin erythromycin
diazepam
warfarin
cholestasis w abx
co-amoxiclav
ace
cough, hyperkal, first dose hypot
check UE before and if increase dose
- 30% creat rise ok
- K ok up to 5.5
avoid ace inhibitors in
AS
renovascular
preg and BF
drugs causing lung fibrosis
methotrexate
amiodarone
furosemide
acts on ascending loop
se: hypo..
tension, cal, kal, nat
EARS - ototoxic
digoxin toxicity
arrythmia
gut: nausea vom diarrhoea
yellow vision
methotrexate monitoring
fbc, ue, lft
amiodarone
lft, tft
breakthrough morphine
6th of daily req
infective exac of copd abx?
amoxicillin
or tetra, or clarth
cellulitis
flucox
epilepsy
sodium valprate
-ntd - take high dose folate in preg
carbamazepine if complex partial
acture pyelonephriti abx
broad spec cephalo
viagra (sildenafil)
contraindicated: nitrates and nicorandil
se: visual disturb
post mi
ace, b, statin, asp
clopidog 4 weeks if stemi
clopidog 12 month if nstemi/unstable angina ONLY IF 6MM>1.5
drugs increasing prolactin (could cause galactorrhoea)
metoclopramide
domperidone
chlopromazine
to treat: dopamine agonist (bromocriptine)
(non drug: preg, hypothy, pit tumour, acromeg, pcos)
P450 INDUCERS (reduce drug avail)
phenytoin, carbamez
barbiturate
rifampicin
chronic alcohol
P450 INHIBITORS
increase drug action ie increase inr if on warfarin
abx eg erythro isoniazid ppi/h2r amiodarone allopurinol ssri sodium valproate acute alcohol
tb treat
rifampicin 6m
isoniazid 6m
first two months:
ethambutol
pyrozinamide
anticoag for DVT
start heparin
start warfarin within 24hr
when INR stable in 2-3 fro 24hrs stop heparin
continue warfarin 3 months
(6 months if cancer)
warfarin
vs extrinsic path (VII,X) measure INR (determined by PT)
heparin
activates antithrombin iii
intrinsic pathway
measure attp for full hep,
measure anti factor X for lmwh
risks bleeding, HIT, osteoporo, hyperkal
orilistat
to help lose weight
panc lipase inhibitor
1 year use if
- bmi>30
- bmi>28 plus risk factor
- good weight loss so far
hypekalaemia mgmt
iv calcium gluconate
insulin glucose
?calcium resonium
?salbutamol
example of thiazide like diuretic
indapamide
treat chlamydia
azithromycin
or doxycycline
if preg erythro or amoxy
allopurinol dose
start at 100mg titrate up (until uric acid is <300)
ciclosporin se
nephrotoxic
sulfasalazine se
rash
oligospermia
anaemia
hydroxycloroquinine se
antimalarial vs ra
retinopathy, corneal deposits
prednisolone
bones, infections, gastric, sleep
weight gain, htn, glucose tol
cushing, cataract
ra drugs causing proteinuria
gold
penicillamine
biological agents se
infliximab. etanercept, adalimumab
rituximab
reactivate tb
rituximab –> infusion reaction
