Pharmocology Flashcards

1
Q

spironalactone se

A

hyperkalaemia

- peak t, small p, wide qrs

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2
Q

ccb for htn

A

nifed, amlod

se - ankle swelling, dizzyness

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3
Q

methotrexate se

A

can get pneumonitis
myelofibrosis
liver fibrosis
renal

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4
Q

animal bite abx

A

co-amoxiclav

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5
Q

drugs in ALS

A

1 mg adrenaline 3-5mins
amiodarone after 3rd shock

not atropine

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6
Q

clindamycin prob

A

commonly linked to c diff

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7
Q

treat c diff

A

metronidazole

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8
Q

cocaine affects

A

heart
neuropsych

hypertension
rhabdo
met acid

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9
Q

statin

A

myopathy
liver probs
- monitor LFT’s before and during
- stop if reach 3 times normal

take at night

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10
Q

amlodipine main se

A

ankle swell

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11
Q

thiazide main se

A

hyponat

others

  • postural hypotension, dehydration
  • hypokal, hypercal
  • gout
  • impaired gluc tol
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12
Q

b-block main side

A

cold periph

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13
Q

what to avoid in renal failure

A

tetracycline
nsaid
metformin
lithium

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14
Q

safe in renal failure

A

rifampicin erythromycin
diazepam
warfarin

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15
Q

cholestasis w abx

A

co-amoxiclav

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16
Q

ace

A

cough, hyperkal, first dose hypot

check UE before and if increase dose

  • 30% creat rise ok
  • K ok up to 5.5
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17
Q

avoid ace inhibitors in

A

AS
renovascular
preg and BF

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18
Q

drugs causing lung fibrosis

A

methotrexate

amiodarone

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19
Q

furosemide

A

acts on ascending loop

se: hypo..
tension, cal, kal, nat
EARS - ototoxic

20
Q

digoxin toxicity

A

arrythmia
gut: nausea vom diarrhoea
yellow vision

21
Q

methotrexate monitoring

A

fbc, ue, lft

22
Q

amiodarone

A

lft, tft

23
Q

breakthrough morphine

A

6th of daily req

24
Q

infective exac of copd abx?

A

amoxicillin

or tetra, or clarth

25
Q

cellulitis

A

flucox

26
Q

epilepsy

A

sodium valprate
-ntd - take high dose folate in preg

carbamazepine if complex partial

27
Q

acture pyelonephriti abx

A

broad spec cephalo

28
Q

viagra (sildenafil)

A

contraindicated: nitrates and nicorandil
se: visual disturb

29
Q

post mi

A

ace, b, statin, asp

clopidog 4 weeks if stemi
clopidog 12 month if nstemi/unstable angina ONLY IF 6MM>1.5

30
Q

drugs increasing prolactin (could cause galactorrhoea)

A

metoclopramide
domperidone

chlopromazine

to treat: dopamine agonist (bromocriptine)

(non drug: preg, hypothy, pit tumour, acromeg, pcos)

31
Q

P450 INDUCERS (reduce drug avail)

A

phenytoin, carbamez
barbiturate
rifampicin
chronic alcohol

32
Q

P450 INHIBITORS

increase drug action ie increase inr if on warfarin

A
abx eg erythro
isoniazid
ppi/h2r
amiodarone
allopurinol
ssri
sodium valproate
acute alcohol
33
Q

tb treat

A

rifampicin 6m
isoniazid 6m

first two months:
ethambutol
pyrozinamide

34
Q

anticoag for DVT

A

start heparin
start warfarin within 24hr
when INR stable in 2-3 fro 24hrs stop heparin

continue warfarin 3 months
(6 months if cancer)

35
Q

warfarin

A
vs extrinsic path (VII,X)
measure INR (determined by PT)
36
Q

heparin

A

activates antithrombin iii
intrinsic pathway
measure attp for full hep,
measure anti factor X for lmwh

risks bleeding, HIT, osteoporo, hyperkal

37
Q

orilistat

A

to help lose weight
panc lipase inhibitor

1 year use if

  • bmi>30
  • bmi>28 plus risk factor
  • good weight loss so far
38
Q

hypekalaemia mgmt

A

iv calcium gluconate
insulin glucose
?calcium resonium
?salbutamol

39
Q

example of thiazide like diuretic

A

indapamide

40
Q

treat chlamydia

A

azithromycin
or doxycycline

if preg erythro or amoxy

41
Q

allopurinol dose

A

start at 100mg titrate up (until uric acid is <300)

42
Q

ciclosporin se

A

nephrotoxic

43
Q

sulfasalazine se

A

rash
oligospermia
anaemia

44
Q

hydroxycloroquinine se

antimalarial vs ra

A

retinopathy, corneal deposits

45
Q

prednisolone

A

bones, infections, gastric, sleep
weight gain, htn, glucose tol
cushing, cataract

46
Q

ra drugs causing proteinuria

A

gold

penicillamine

47
Q

biological agents se
infliximab. etanercept, adalimumab
rituximab

A

reactivate tb

rituximab –> infusion reaction