PharmFinal/unfinished

Question 1

Does methotrexate cross the BBB?

Answer 1

no, must give it IT. look to make sure it is the syringe has yellow in it

Question 2

methotrexate should be check for what before giving intrathecally?

Answer 2

make sure it is preservative free

Question 3

What is the antidote for methotrexate?

Answer 3

Calcium leucovorin and levoleucovorin

Question 4

ADRs of methotrexate?

Answer 4

bone marrow suppression, mucositis
hepatotoxicity
can crystallize in the urine

Question 5

Which drug must you add folic acid and B12 to to minimize life threatening toxicities?

Answer 5

pemetrexed

Question 6

What drug is used to maintain remission of ALL?

Answer 6

mercaptopruine and methotrexate

Question 7

What drug when given requires decadron eye drops since it causes allergic conjunctivitis in high doses?

Answer 7

PYRIMIDINE ANTAGONISTS

i.e. Cytarabine (Ara-C) Fluorouracil (5-FU)

Question 8

What drug is applied topically to treat skin cancer and actinic keratosis?

Answer 8

fluorouracil

Question 9

What drugs most commonly cause mucositis?

Answer 9

Bleomycin
Cytarabine
Doxorubicin
5-FU (bolus administration schedules)
Methotrexate (particularly low-dose)

Question 10

What drug is used to treat sick cell or a blast crisis?

Answer 10

hydroxyurea

Question 11

what drug needs to be given with mesna to decrease the incidence of hemorrhagic cystitis?

Answer 11

cyclophosphamide and ifosfamide

Question 12

What drug is used for CLL?

Answer 12

chlorambucil

Question 13

What drug is give with platinum compounds to decrease renal tubule damage?

Answer 13

mannitol. it binds to the cisplatin and increases U/O

Question 14

What drug can cause pulmonary fibrosis??

Answer 14

busulfan

Question 15

What drug can be given intravesically for bladder cancer?

Answer 15

mitomycin.can also cause severe pulmonary damage

Question 16

first line therapy for brain tumor?

Answer 16

temozolamide

Question 17

Anthracyclines cause?

Answer 17

cardiotoxicitiy!!!

Question 18

T/F bleomycin can cause pulmonary toxicity.

Answer 18

True. and

Question 19

What drug causes dose-limiting neurotoxicity?

Answer 19

vincristine. peripheral neuropathy, deep tendon reflex suppression…

Question 20

What drug is fatal if given intrathecally?

Answer 20

vinblastine