Pharmacotherapy of airflow obstruction

Question 1

What 2 categorizes that drugs for airflow obstruction?

Answer 1

Preventors (anti-inflammatory)

Relievers (bronchodialators)

Question 2

What is the first stage of inflammatory stages in asthma?

Answer 2

Inherited or acquired factors

• genetic predisposition
• viral, antigen or chemical

Question 3

What is the second stage of inflammatory stages in asthma?

Answer 3

Eosinophilic inflammation

Question 4

What is the third stage of inflammatory stages in asthma?

Answer 4

Mediators - Th2 cytokines

Question 5

What is the forth stage of inflammatory stages in asthma?

Answer 5

Twitchy smooth muscle (hyperreactivity)

Question 6

What is the treatment/prevention of the first stage of inflammatory stages in asthma?

Answer 6

Inherited or acquired factors - Avoidance of precipitant

Question 7

What is the treatment/prevention of the second stage of inflammatory stages in asthma?

Answer 7

Eosinophilic inflammation - anti-inflammatory medication

• cortisosteriods
• cromones
• theophylline

Question 8

What is the treatment/prevention of the third stage of inflammatory stages in asthma?

Answer 8

Mediators - Antileukotrienes or antihistamines monoclonal antibodies

• Anti-IgE
• anti-interleukin 5

Question 9

What is the treatment/prevention of the forth stage of inflammatory stages in asthma?

Answer 9

hyperreactivity

• B2 antagonists
• Muscarinic antagonists

Question 10

What are the 4 stages in asthma treatment in order of severity?

Answer 10

Short-acting B2 antagonists
Inhaled Steroid
Theophyline
Oral steroid/biologics