Pharmacology Week 2 Lecture Flashcards
_________: substances which initiate a response in the neuro-effector tissue. There is usually a maximum response which cannot be exceeded. Substances which give this maximum response are ____ ______.
AGONISTS
full agonists
_______ _________: substances which initiate less than the ________ response in neuro-effector tissue.
PARTIAL AGONISTS
maximal
___________ or _________: prevent an agonist from initiating a response at the receptor. Usually _________ have no activity at the receptor.
ANTAGONISTS
BLOCKERS
antagonists
________ _________: the process by which a receptor blocker prevents access of the agonist to the receptor but if the agonist concentration is increased the ________ ________ will be displaced and response will occur.
COMPETITIVE ANTAGONISM
competitive antagonist
_________ : refers to the dose or concentration needed to elicit a standard response. _______ drugs require the lowest concentration
POTENCY
Potent
_______: the ease with which a drug combines with it’s receptor.
AFFINITY
What is EFFICACY or INTRINSIC ACTIVITY ?
A measure of the ability of a drug to initiate a response
Use is restricted to agents with agonist actions
_______ have both affinity and efficacy
________ have affinity but no efficacy
_______ agonists have affinity but lower efficacy than full agonists
Agonists
Antagonists
Partial
Several different types of receptor are:
(1)metabotropic or G-protein coupled (2)ionotropic leading to a change in voltage across the membrane
Most receptors are ____ ______ _______
cell surface receptors
Receptors are _______ found in ______ ________
Proteins
cell membranes
Function of _-_______is to transmit messages from _______ to ______
G-proteins
receptors
effectors
Criteria for a receptor
saturability
specificity
reversability
